作　　者： (翟宏军）; (张心武）; (孙晓力）; (马双余）;

机构地区： 西安交通大学第二附属医院普外科,陕西西安710004

出　　处： 《海南医学院学报》 2017年第14期1892-1895,共4页

摘　　要： 目的:研究重症急性胰腺炎(SAP)患者血清炎性因子含量与全身靶器官损伤的关系。方法:选择在本院诊断为重症急性胰腺炎的85例患者作为SAP组,选择同期体检的100例健康志愿者作为对照组,检测血清中炎性因子、肝功能损伤指标、肾功能损伤指标、肠黏膜屏障功指标及尿液中肾功能损伤指标。结果:SAP组血清中PCT、TNF-α、CRP、HMGB-1、ALT、AST、TBIL、BUN、Scr、CysC、DAO、D-乳酸、Occludin、ZO-1的含量及尿液中NGAL、KIM-1的含量均显著高于对照组;SAP患者血清中PCT、TNF-α、CRP、HMGB-1含量与血清中ALT、AST、TBIL、BUN、Scr、CysC、DAO、D-乳酸、Occludin、ZO-1含量及尿液中NGAL、KIM-1含量呈正相关。结论:SAP患者血清中炎性因子的异常释放会引起肝功能、肾功能、肠黏膜屏障功能损伤。 Objective：To study the relationship between serum inflammatory factor levels and systemic target organ damage in patients with severe acute pancreatitis.Methods：A total of 85 patients who were diagnosed with severe acute pancreatitis in the Second Affiliated Hospital of Xi＇an Jiaotong University between June 2013 and August 2016 were enrolled in SAP group,and 100 healthy volunteers who received physical examination during the same period were enrolled in control group.Then serum inflammatory factors,liver function injury indexes,renal function injury indexes and intestinal mucosal barrier function indexes as well as urine renal function injury indexes were determined.Results：Serum PCT,TNF-α,CRP,HMGB-1,ALT,AST,TBIL,BUN,Scr,CysC,DAO,D-lactate,Occludin and ZO-1levels as well as urine NGAL and KIM-1levels of SAP group were significantly higher than those of control group;serum PCT,TNF-α,CRP and HMGB-1levels of patients with SAP were positively correlated with serum ALT,AST,TBIL,BUN,Scr,CysC,DAO,D-lactate,Occludin and ZO-1levels as well as urine NGAL and KIM-1levels.Conclusions：Abnormal release of inflammatory factors in serum of SAP patients can cause the injury of liver function,renal function and intestinal mucosal barrier function.

关 键 词： 重症急性胰腺炎 炎性因子 肝功能 肾功能 肠黏膜屏障