作　　者： (谢建平）; (白建文）;

机构地区： 同济大学附属东方医院急诊内科,上海200120

出　　处： 《中国急救医学》 2017年第9期860-863,共4页

摘　　要： 中性粒细胞胞外捕获（NETs）是中性粒细胞受到炎症刺激后释放至细胞外的一组具有抗菌活性的物质，主要构成成分为解聚的DNA、组蛋白和颗粒蛋白。NETs可以诱捕并杀伤进入体内的病原体，从而阻止感染的传播，但同时具有细胞毒性，可引起内皮损伤和血管渗漏，促进凝血及血栓形成，引起微循环障碍。NETs在肺内的过度形成以及清除障碍在急性肺损伤（Au）的发病机制中起着重要的作用，针对NETs的靶向治疗可能为攻克Au提供新的有益的思路。 Neutrophil extracellular traps （NETs） are decondensed DNA expelled mainly by neutrophils during a process termed NETosis. NETs can bind various pathogens, immobilize or ＂trap＂ them, and uhimately promote their killing to prevent the spread of infection. However, the ineffective clearance or excessive formation of NETs plays an important role in the pathogenesis of acute lung injury （ALI）. NETs and especially NET - bound components such as histones are cytotoxic causing endothelial damage and vascular permeability. NETs are also potent activators of coagulation and have been identified as drivers of organ failure due to disruption of the microcirculation. Therapeutic targeting of NETs may provide a novel approach to combat ALI in humans.

关 键 词： 中性粒细胞胞外捕获 急性肺损伤 发病机制