作　　者： (于向洋）; (贾莉莉）; (喻文立）; (翁亦齐）; (杜洪印）;

机构地区： 天津医科大学一中心临床学院,天津300192

出　　处： 《中国医师杂志》 2017年第8期1278-1280,F0003,共4页

摘　　要： 肾脏作为人体重要的排泄及内分泌器官，在维持机体内环境稳态中发挥重要作用。肾脏病的发生发展，与肾小球滤过屏障功能异常和肾间质重塑密切相关。基质金属酶-9（MMP-9）是细胞外基质（ECM）的主要酶类，通过调节ECM成分及其与细胞因子相互作用，在。肾脏病进程中发挥重要作用。该文将阐述MMP-9在肾小球滤过屏障功能障碍和。肾纤维化中的病理生理作用，为肾脏病的临床治疗提供理论依据。 Kidney plays an important role in maintaining the homeostasis as an important excretory and endocrine organ. The occurrence and development of kidney disease is closely associated with glomerular filtration barrier dysfunction and renal interstitial remodeling. Matrix metalloproteinase-9 （ MMP-9）, a major enzyme in the extracellular matrix （ECM）, plays an important role in the process of kidney disease by regulating the ECM components and its interaction with cytokines. The paper reviews the pathophysiology of MMP-9 in glomerular filtration barrier dysfunction and renal fibrosis to provide a theoretical basis for clinical treatment of kidney disease.

关 键 词： 基质金属蛋白酶 肾疾病 综述