作　　者： (徐文韬）; (李一阳）; (倪光夏）;

机构地区： 南京中医药大学,江苏南京210046

出　　处： 《辽宁中医药大学学报》 2017年第8期53-59,共7页

摘　　要： 脑缺血再灌注损伤主要是指缺血脑组织恢复血液灌注后脑组织损伤反而加重,表现为其神经损害体征和形态学改变,有时会较前更加明显等。血脑屏障是存在于脑组织和血液之间的一个复杂的系统,能控制血脑两侧的物质转运从而保证中枢神经组织内环境的相对稳定。血脑屏障的损伤在脑缺血再灌注损伤的发生及发展中起重要作用。多种因素参与了血脑屏障结构和功能的改变,而这些变化则是脑缺血再灌注损伤病理变化的重要环节之一。针灸是目前公认的治疗缺血性脑血管病的有效疗法,能有效的抑制脑缺血发生后产生的级联反应及神经元损伤。因此,该文对影响血脑屏障改变的因素及其血脑屏障与脑缺血再灌注损伤之间的关系进行综述,并探讨针刺干预脑缺血再灌注损伤的可能机制。 Cerebral ischemia reperfusion injury is mainly refers to ischemic brain tissue to restore blood perfusion afterbrain tissue damage aggravate performance for nerve damage signs and morphological change sometimes, more apparent, such as earlier. The blood-brain barrier is exist in the brain tissue and btood between a complex system can control the blood transport on either side of the brain and central nervous tissues environment is relatively stable. The blood-brain barrier damage in cerebral ischemia reperfusion injury play an important role in the occurrence and development. Many factors involved in the structure and function of the blood-brain barrier to change, and these changes are cerebral ischemia-reperfusion injury pathological changes of one of the important link. Acupuncture is now recognized as effective in the treatment of ischemic eerebrovascular disease, can effectively inhibit produced after onset of ischemic cascade reaction and neuron injury. Therefore, in this paper, the factors affecting blood-brain barrier change and blood brain barrier and the relationship between the cerebral ischemia-reperfusion injury were reviewed, and acupuncture intervention, possible mechanisms of cerebral ischemia-reperfusion injury.

关 键 词： 脑缺血再灌注 血脑屏障 针刺