作　　者： (高燕）; (刘岩）; (翟金国）;

机构地区： 济宁医学院精神卫生学院,山东济宁272067

出　　处： 《四川精神卫生》 2017年第4期379-383,共5页

摘　　要： 抑郁症是一常见的精神障碍,多呈慢性、复发性病程。目前,药物治疗仍然是最常用治疗方法。然而,有些患者对单一抗抑郁药物系统治疗反应不佳,即通常所称的难治性抑郁症(TRD)。针对TRD的治疗已有多种疗法,其中之一为抗抑郁药物的联合治疗,即同时用两种或以上的抗抑郁药物治疗,如米氮平联合SSRIs等。本文就目前抗抑郁药联合治疗TRD的研究进展进行综述。 Depressive is a common mental disorder with a chronic and recurrent process. Currently, the most commonly employed treatment is antidepressant medication. However, some patients, which are usually regarded as treatment - resistant depression （TRD）,did not respond to standard treatment with antidepressant medications. Various therapies have been put forward to treating TRD. Among which, one strategy is a combination of antidepressant treatment, which is using two or more antidepressants simultaneously, such as mirtazapine combined with SSRIs. This article mainly reviewed the current research progress of combination treatment for TRD.

关 键 词： 抑郁症 难治性抑郁症 抗抑郁药 联合治疗