作　　者： (李晶晶）; (梅刚）; (瞿秋霜）; (李海林）;

机构地区： 南京医科大学附属脑科医院,江苏南京210029

出　　处： 《四川精神卫生》 2017年第4期341-344,共4页

摘　　要： 目的分析老年精神分裂症患者血浆脂蛋白磷脂酶A2(Lp-PLA2)浓度及与简明精神病评定量表(BPRS)评分的相关性,探讨血浆Lp-PLA2浓度在老年精神分裂症发病中的作用。方法采用简单随机抽样方法选取2015年1月-12月在南京医科大学附属脑科医院住院的老年精神分裂症患者为病例组(n=72),以同时段在本院体检的所有健康退休员工为对照组(n=72)。采用免疫增强比浊法检测两组血浆Lp-PLA2浓度,使用简明精神病评定量表(BPRS)评定老年精神分裂症患者的精神症状,分析BPRS评分与血浆Lp-PLA2浓度的相关性。结果病例组血浆Lp-PLA2浓度高于对照组[(232.5±125.7)ng/m L vs.(185.4±74.6)ng/m L,t=2.734,P<0.05]。61例慢性病例组血浆Lp-PLA2浓度与11例首发病例组比较,差异无统计学意义[(119.8±15.3)ng/m L vs.(160.4±48.4)ng/m L,t=0.479,P>0.05]。老年精神分裂症病例组BPRS评分为(50.9±10.5)分,与血浆Lp-PLA2浓度无相关性。结论老年精神分裂症患者可能存在膜磷脂代谢异常,血浆Lp-PLA2浓度可能不能作为判断老年精神分裂症临床症状严重程度的标准。 Objective To investigate the relationship between plasma lipoprotein - associated phospholipase A2（Lp -PLA 2 ） concentration and the Brief Psychiatric Rating Scale （BPRS） scores in elderly patients with schizophrenia, and to explore the role of plasma Lp - PLA2 in the pathogenesis of elderly schizophrenia. Methods The simple random sampling method was used to select 72 elderly patients with schizophrenia who were hospitalized in Affiliated Brain Hospital of Nanjing Medical University from January to December 2015. At the same time, this study recruited 72 healthy retired employees as the control group. The plasma Lp - PLA2 concentration was measured by immune enhancement turbidimetry. Psychiatric symptoms of elderly schizophrenia patients were assessed with BPRS. The correlation between BPRS scores and plasma Lp - PLA2 concentration was analyzed. Results The plasma Lp - PLA2 concentration of the study group was higher than the control group[ （232. 5 ± 125. 7） ng/mL vs. （ 185. 4 ± 74. 6） ng/mL,t =2. 7 3 4, P 〈0. 05]. There was no significant difference in the plasma Lp - PLA2 concentration of between 61 chronic elderly schizophrenic patients and 11 late - onset schizophrenic patients [（ 119. 8 ± 15. 3 ） ng/mL vs. （ 160. 4 ±48. 4） ng/mL,t=0. 4 7 9 , P 〉 0. 05 ] . The plasma Lp - PLA2 concentrations was not correlated with BPRS scores in elderly schizophrenic patients. Conclusion Elderly schizophrenic patients may have abnormal membrane phospholipid metabolism, plasma Lp - PLA2 can not be used to determine the severity of clinical symptoms of them.

关 键 词： 血浆脂蛋白磷脂酶 老年精神分裂症 脂质代谢