机构地区: 南京医科大学康达学院,连云港222000
出 处: 《价值工程》 2017年第28期187-189,共3页
摘 要: 目的:研究荷电药物与相反电荷表面活性剂混合物的理化性质及体外释放。方法:通过调节DH/AOT摩尔比,阴阳离子聚集体呈现不同带电特性,结构,以及由于聚集体的结构改变可影响药物的释放行为。结果:载药阴阳离子囊泡可作为缓释的载体。结论:阴阳离子囊泡可作为一种新型的药物缓释载体。 Objective: To study the physical and chemical properties and release in vitro of charged drugs and oppositely charged surfactant mixtures. Methods: By adjusting the molar ratio of MH/AOT, the cation and cation aggregates exhibit different charging characteristics, structures and the release behavior of the drug due to the structural change of the aggregates. Results: Carrier cation and anion vesicles can be used as carriers for sustained release. Conclusion: The vesicles can be used as a new type of drug delivery carrier.