作　　者： (李缓）; (陈奎）; (王园）; (王勇）;

机构地区： 河南大学化学化工学院,河南开封475004

出　　处： 《化学研究》 2017年第4期493-500,共8页

摘　　要： 将纳米纤维素(NCC)表面接枝丁二酸酐得到丁二酸酐化纳米纤维素(NCSA),再将阳离子表面活性剂十六烷基三甲基溴化铵(CTAB)负载到NCSA,得到一种新的纳米药物载体(CTAB@NCSA).考察了NCSA的物理化学性能,包括扫描、透射电镜,红外光谱,X射线粉末衍射及电位测定;同时研究了NCSA对CTAB的吸附行为.最后以CTAB@NCSA为药物载体,以LUT和LUS为模型药物,通过分子间作用力及疏水作用力得到负载LUT和LUS的纳米复合物微球CTAB@NCSA@LUT和CTAB@NCSA@LUS,并对其体外释药进行了研究. Succinic anhydride-grafted nanocrystalline cellulose labeled NCSA was developed and further modified with cetyltrimethylammonium bromide（CTAB）labeled CTAB@NCSA as a novel drug delivery excipient which was used to modulate the loading of hydrophobic drugs.The morphology and structure of the NCSA before and after modification were characterized by scanning electron microscopy（SEM）,transmission electron microscopy（TEM）,Fourier transform infrared spectroscopy（FT-IR）,X-ray powder diffraction（XRD）and zeta potential.Furthermore,the adsorption kinetics and isotherm analysis of NCSA for CTAB were employed to explain in-depth information associated with the adsorption process.The adsorption kinetics fitted well to the pseudo-second-order model and isothermal study demonstrated a multilayered adsorption following Temkin model.Hydrophobic luteolin（LUT）and luteoloside（LUS）were used as model drugs for the investigation of drug loading and release performance.The CTAB@NCSA exhibited high drug loading capability and long sustained release time.These findings prefigure the promising potentials of CTAB@NCSA as a carrier for hydrophobic LUT and LUS.

关 键 词： 木犀草素及其苷 丁二酸酐 纳米纤维素 表面活性剂 体外释放