作　　者： (王斐）; (李嫔）;

机构地区： 上海市儿童医院上海交通大学附属儿童医院内分泌科,上海200040

出　　处： 《中国实用儿科杂志》 2017年第9期660-664,共5页

摘　　要： 儿童骨骼存在呈纵向生长和骨转换较快的特点,骨代谢标记物浓度能早期灵敏地反映骨代谢转换动态状况,可用来评估生长发育状态,了解骨骼代谢疾病的病理生理以及监测治疗效果。不同年龄、种族、性别、青春发育的不同阶段、激素调控、营养状态、昼夜变化及骨代谢疾病都会影响儿童骨代谢标记物浓度的检测及正常参考值的建立。该文对骨形成和骨吸收标记物的研究进展及其在儿科临床中的应用进行了阐述。 The skeletal features of children are longitudinal growth and faster conversion of bone. Bone metabolism markers can sensitively reflect early bone metabolism status, which is useful in assessing growth situation, understanding the pathophysiology of metabolic bone disease and monitoring treatment. The different stages of age, race, sex, puberty, hormone regulation, nutritional status, diurnal changes and metabolic bone diseases can all affect the determination of bone metabolism markers in children and the establishment of the normal reference values. In this review, we will review the advances in bone formation and bone resorption markers and their applications in pediatric clinical practice.

关 键 词： 儿童 骨形成 骨吸收 骨代谢标记物