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基于统计参数图的脑内不对称分析法在^18F-FDG PET代谢显像对单侧颞叶癫痫定侧定位诊断上的应用
Statistical parametric mapping-based interhemispheric asymmetry analysis of ^18F-FDG PET brain imaging in localization of unilateral temporal lobe epileptic foci

作  者: (王晓阳); (赵春雷); (李辉); (付丽媛); (林丹丹); (陈自谦);

机构地区: 南京军区福州总医院医学影像中心,350025

出  处: 《中华核医学与分子影像杂志》 2017年第9期538-543,共6页

摘  要: 目的评价基于SPM的脑内不对称分析法在^18F-FDG PET代谢显像对单侧难治性颞叶癫(TLE)患者致灶辅助定侧定位诊断中的应用价值。方法回顾性分析2012年3月至2015年7月间73例[男42例、女31例,平均年龄(27.10±9.78)岁]单侧TLE患者及30名[男17名、女13名,平均年龄(33.79±5.46)岁]健康对照组的临床及影像学资料。通过^18F-FDG PET/CT检查对TLE患者主要致灶进行定侧定位,^18F-FDG PET图像分析采用基于SPM的脑内不对称分析法、视觉分析法及不对称指数(AI)分析法。综合术后病理及预后,比较3种方法对单侧TLE患者主要致灶的检出符合率。数据分析采用χ^2分析及χ^2分割检验。结果运用基于SPM的脑内不对称分析法、视觉分析法及AI分析法对单侧TLE患者定侧定位诊断符合率分别为87.67%(64/73)、75.34%(55/73)及69.86%(51/73),差异有统计学意义(χ^2=6.993,P〈0.05);两两比较的结果显示,脑内不对称分析法与AI分析法、脑内不对称分析法与视觉分析法间差异有统计学意义(χ^2值:8.481和5.818,均P〈0.017),视觉分析法与AI分析法间差异无统计学意义(χ^2=0.500,P〉0.017),脑内不对称分析法的符合率明显高于视觉分析法及AI分析法。结论基于SPM的脑内不对称分析法可以相对客观、准确地对单侧难治性TLE患者的主要致灶进行定位,有较高的临床应用价值。 Objective To evaluate the diagnostic value of the SPM-based interhemispheric asymmetry analysis (SIAA) of ^18F-FDG PET brain imaging in localization of temporal lobe epileptic foci. Methods A total of 73 patients (42 males, 31 females, average age: (27.10±9.78) years) diagnosed as temporal lobe epilepsy (TLE) and 30 healthy volunteers (17 males, 13 females, average age: (33.79±5.46) years) from March 2012 to July 2015 were enrolled in this retrospective study. ^18F-FDG PET brain imaging was performed on all subjects to localize temporal lobe epileptic foci. The results of ^18F-FDG-PET were analyzed by SIAA, visual analysis and asymmetry index (AI) analysis. The accuracy of the three methods was evaluated according to the postoperative pathological results and curative effect. Х^2 test and partition of Х^2 test were used to analyze the data. Results The accuracies of localization with SIAA, visual analysis and AI analysis were 87.67% (64/73) , 75.34% ( 55/73 ) and 69.86% ( 51/73 ) , respectively (Х^2 = 6.993, P〈 0. 05 ). The accuracy of SIAA was higher than that of visual analysis and AI analysis (Х^2 values: 5.818 and 8.481, both P〈0.017), while there was no significant difference between AI analysis and visual analysis (Х^2=0.500, P〉0.017). Conclusion The SIAA of ISF-FDG PET brain imaging may be a more objective and accurate method in localization of TLE foci.

关 键 词: 癫痫 颞叶 诊断 正电子发射断层显像术 体层摄影术 线计算机 图像处理 计算机辅助 脱氧葡萄糖

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