作　　者： (王衍洪）; (莫炫永）; (肖俏霞）; (孙凌瑜）; (黎秀平）; (曾丽萍）; (何珊娜）;

机构地区： 中山大学附属东华医院,广东东莞523110

出　　处： 《中国药物经济学》 2017年第8期49-52,共4页

摘　　要： 目的探讨马来酸依那普利叶酸片与不同厂家马来酸依那普利片联用叶酸片的相对生物利用度。方法 20名健康人群按照以下三个组别:对照组口服马来酸依那普利叶酸片(含依那普利10 mg/叶酸0.8 mg)、试验1组口服马来酸依那普利片(悦宁定)10 mg和叶酸片0.8 mg、试验2组口服马来酸依那普利片(依苏)10 mg和叶酸片0.8 mg,单剂量口服,经过清洗期后交换组别,保证每名受试者都能经历三组试验,对三种用药方案进行生物等效性评价。结果 20名健康人群经三种用药方案治疗后,试验组与对照组的血药浓度及血药浓度-时间曲线相比差异无统计学意义(P>0.05)。结论马来酸依那普利叶酸片和马来酸依那普利片加叶酸片具有相同的血药浓度及药时曲线,具有生物等效性。 Objective To investigate the plasma concentration of enalapril maleate tablets and different manufacturers of enalapril maleate plus folic acid tablets for H-type hypertension.Methods Thirty healthy people according to the following three groups.The control group was treated with enalapril follicles（Yi Ye）（containing enalapril 10 mg/folic acid 0.8 mg）,the test group 1 oral administration of enalapril tablets（Yue Ning Ding） 10 mg and folic acid tablets 0.8mg,For the test group 2 oral administration of enalapril tablets（Yi Su） 10 mg and folic acid tablets 0.8 mg,a single dose of oral,after cleaning the exchange group,to ensure that everyone has experienced three groups of experiments.Result There was no significant difference between the experimental group and the control group in the plasma concentration and the time curve of the three groups（P〈0.05）.Conclusion The enalapril maleate and maleic acid Enalapril tablets plus folic acid tablets have the same drug profile,and bioequivalent.

关 键 词： 马来酸依那普利叶酸片 马来酸依那普利片加叶酸片 药时曲线