作　　者： (仲婷）; (王泽斌）;

机构地区： 新疆维吾尔自治区人民医院,新疆乌鲁木齐830000

出　　处： 《中国妇幼保健》 2017年第17期4085-4087,共3页

摘　　要： 目的探究卡马西平联合叶酸治疗妊娠期癫痫效果及对母婴结局的影响。方法将2013年10月-2016年6月该院收治的82例妊娠期癫痫患者根据入院时间分为观察组和对照组,每组各41例。对照组服用卡马西平,观察组服用卡马西平加叶酸,观察并记录两组患者妊娠期癫痫发作程度、发作次数、胎儿妊娠结局及并发症发生情况。结果观察组孕妇妊娠期癫痫发作6例,发作率为14.63%;对照组孕妇妊娠期癫痫发作17例,发作率为41.47%,两组比较差异有统计学意义(P<0.05)。观察组孕妇出现妊娠高血压综合征、癫痫发作以及抑郁症等并发症概率显著低于对照组(P<0.05);两组孕妇流产、早产以及前置胎盘例数比较差异无统计学意义(P>0.05)。观察组新生儿畸形率为7.32%,对照组为29.27%,两组比较差异有统计学意义(P<0.05);两组出现死胎、胎儿宫内窘迫和低出生体重儿的概率比较差异无统计学意义(P>0.05)。结论卡马西平联合叶酸治疗妊娠期癫痫效果较好,癫痫发作情况得到有效控制,孕妇妊娠高血压综合征、围生期癫痫发作以及新生儿畸形、低出生体重儿等不良事件发生概率显著降低。 Objective To explore the effect of carbamazepine combined with folic acid in treatment of epilepsy during pregnancy and its impact on maternal and fetal outcomes.Methods According to the admission time,82 patients with epilepsy during pregnancy were selected from the hospital from October 2013 to June 2016,then they were divided into observation group and control group,41 patients in each group.The patients in control group were treated with carbamazepine,and the patients in observation group were treated with carbamazepine combined with folic acid.The degrees of epilepsy,the frequencies of attack,pregnancy outcomes,and complications were observed and recorded in these two groups.Results The incidence rate of seizures was 14.63% （6 cases） in observation group.The incidence rate of seizures was 41.47% （17 cases） in control group.There was statistically significant difference between the two groups （P〈0.05）.The incidence rates of complications such as hypertensive disorder complicating pregnancy （HDCP）,seizures,and depression in observation group were statistically significantly lower than those in control group （P〈0.05）.However,there was no statistically significant difference in the numbers of patients with abortion,preterm birth,and placenta previa between these two groups （P〉0.05）.The incidence rates of neonatal malformations were 7.32% in observation group and 29.27% in control group,there was statistically significant difference between the two groups （P〈0.05）.There was no statistically significant difference in the incidence rates of stillbirth,fetal intrauterine distress,and low birth weight infant between the two groups （P〉0.05）.Conclusion The effect of carbamazepine combined with folic acid in treatment of patients with epilepsy during pregnancy is good,and seizures are effectively controlled.The incidence rates of adverse events such as HDCP,perinatal epilepsy seizures,neonatal malformations,low birth weight significantly reduce.

关 键 词： 卡马西平 叶酸 妊娠期 癫痫