作　　者： (张芳）; (林文生）; (李腾）; (郑吉春）; (任力）;

机构地区： 空军总医院病理科,北京100142

出　　处： 《诊断病理学杂志》 2017年第8期576-580,共5页

摘　　要： 目的探讨肺原发性霍奇金淋巴瘤的临床病理学特征。方法结合组织形态和免疫组化对1例肺原发性霍奇金淋巴瘤进行临床病理分析,并复习相关文献。结果患者女性,28岁。肿瘤位于右肺上叶,组织学表现炎症背景中可见异型增生的淋巴样细胞散在分布,细胞体积大,异型性明显,可见不典型的双核R-S细胞。免疫组化示肿瘤细胞CD30(+)、PAX-5(弱+)、部分肿瘤细胞CD20(弱+),LCA、CD56、ALK、S-100和HMB-45均(-),EBER原位杂交(-)。结论肺原发性霍奇金淋巴瘤非常罕见,无明显的临床特征,组织学及影像学表现易与其他肺部疾病混淆,病理诊断肺原发性霍奇金淋巴瘤应与纵隔(胸腺)大B细胞性淋巴瘤、间变性大细胞性淋巴瘤、肺大细胞癌、朗格汉斯细胞组织细胞增生症、恶性黑色素细胞瘤鉴别。 Objective To discuss and summarize the clinical pathological characteristics of primary pulmonary Hodgkin Lymphoma. Methods A case of primary pulmonary Hodgkin Lymphoma was carefully studied by histopathologic and immunohistochemistry,with general review of literatures. Results Tumor from superior lobe of right lung of a 28-yearold woman was analyzed. Histological examination showed large atypical hyperplastic lymphoid cells scattered in background of inflammation. Occasionally,atypical R-S cells were observed. Immunohistochemical staining showed that tumor cells were positive for CD30,moderate staining of PAX-5,and partially positive for CD20; The tumor was negative for LCA,CD56,ALK,S-100,HMB-45. EBER in situ hybridization was negative in this case. Conclusion Primary pulmonary Hodgkin Lymphoma is a rare malignant tumor. It is hard to diagnose due to its nonspecific clinical symptoms,and easy to confuse with other lung diseases both in histological and radiological results. It should be distinguished from diffuse large B cell lymphoma,anaplastic large cell lymphoma,large cell carcinoma,Langerhan’s cell histiocytosis,and malignant melanoma.

关 键 词： 霍奇金淋巴瘤 病理特点 肺淋巴瘤