作　　者： (宫丽丽）; (李连庆）; (刘莉莉）; (段文超）; (武珂）;

机构地区： 聊城市人民医院耳鼻喉科,252000

出　　处： 《国际医药卫生导报》 2017年第18期2867-2869,共3页

摘　　要： 目的探析中晚期咽喉肿瘤患者不同治疗方法后的生存率、喉功能保留率。方法选择本院收治的58例中晚期咽喉肿瘤患者作为研究对象展开回顾性分析，根据手术方式的不同分为观察组（n=36）和对照组（n=22）。对照组应用喉全切除术，观察组患者应用喉部分切除术，比较两组患者的生存率、发音效果以及喉部功能的恢复情况。结果观察组患者中共有25例（69．44％）的发音效果为Ⅳ级，9例（25．00％）为Ⅲ级，均明显多于对照组，差异有统计学意义（P〈0．05）；观察组患者的基频（F0）、标准化噪声能量（HNR）、振幅微扰（Shimmer）、频率微扰（Jitter）等声学参数均明显低于对照组，提示该组患者的嗓音质量更好，两组比较差异均有统计学意义（均P〈0．05）。观察组患者1、3、5年生存率分别为86．1％、50．0％、13．9％，均明显高于对照组的68．2％、31．8％、4．5％，两组比较差异均有统计学意义（均P〈0．05）。结论与喉全切除术相比，喉部分切除术的针对性更高，可以有效减轻手术对喉部造成的损伤，最大限度的保留喉部功能，效果较好，值得推广。 Objective To investigate the survival rate and the retention rate of laryngeal function of different treatment methods for patients with middle and advanced laryngeal cancer. Methods 58 patients with middle and advanced laryngeal cancer in our hospital were selected as the research object, and divided into the observation group and the control group according to the different surgical methods. The patients in the control group were treated with total laryngectomy, while the patients in the observation group were treated with partial laryngectomy. The survival rate, the pronunciation, and the recovery of laryngeal function were compared between the two groups. Results There were 25 cases （69.44%） of class IV pronunciation effect and 9 cases （25%） of class III pronunciation effect in the observation group, significantly higher than those in the control group, with statistically significant differences （P〈0.05）. F0, HNR, Shimmer, Jitter, and other acoustic parameters in the observation group were significantly lower than those in the control group, which suggested better voice quality in the observation group, with statistically significant differences between the two groups （P〈0.05）. The l, 3, 5-year survival rates of the observation group were 86.1%, 50.0%, 13.9%, significantly higher than 68.2%, 31.8%, 4.5% of the control group, with statistically significant differences between the two groups （P〈0.05）. Conclusion Compared with total laryngectomy, partial laryngectomy is more targeted, can effectively reduce the damage caused by the operation of the larynx, to maximize the preservation of laryngeal function, with good effect, worthy of promotion.

关 键 词： 喉部 发音功能 中晚期咽喉肿瘤