作　　者： (陆艳荣）; (阿衣古丽）; (吴旻）; (李曾艳）; (巴尔夏古丽）;

机构地区： 新疆医科大学附属肿瘤医院胸腹放疗科,乌鲁木齐,830011

出　　处： 《中国医师进修杂志》

摘　　要： 目的 探讨食管鳞癌组织中AGGF1的表达,并分析与食管鳞癌临床特征及预后的关系.方法 采用免疫组化SP法对收治的70例食管鳞癌和30例正常食管组织中AGGF1进行检测,并对其表达与食管鳞癌临床特征及预后进行相关性分析.结果 AGGF1在食管鳞癌组织中的阳性表达率高于正常食管组织[54.29%(38/70)比23.33%(7/30)](P=0.004).食管鳞癌中AGGF1的阳性表达与食管鳞癌TNM分期、临床分期、组织病理学及预后密切相关(P均<0.05).AGGF1阳性表达者总生产时间较阴性表达者短[(19.7±3.5)个月比(33.2±4.0)个月],差异有统计学意义(P=0.015).Cox多因素回归分析显示,AGGF1及VEGF阳性表达(P=0.043、0.024)、临床分期(P=0.035)是食管鳞癌患者生存预后的独立影响因素.结论 AGGF1在食管鳞癌组织中高表达,并与食管鳞癌临床病理因素、生存预后密切相关. Objective To investigate the expressions of AGGF1 in esophageal squamous cell carcinoma (ESCC) and their relationships with clinical features and prognosis of ESCC. Methods The expressions of AGGF1 in 70 cases of ESCC and 30 cases of normal esophageal tissue were examined using SP immunohistochemical staining and were analyzed according to the clinical features and follow-up data. Results The expressions of AGGF1 in 70 cases of ESCC was significantly higher than those in 30 cases of normal esophageal tissue [54.29%(38/70) vs. 23.33%(7/30)](P=0.004). The expressions of AGGF1 in ESCC were significantly related to the TNM stage, clinical stage and prognosis (P all<0.05). The OS was shorter in the positive teams of AGGF1 than that in the negative teams [(19.7 ± 3.5) months vs. (33.2 ± 4.0) months] (P=0.015). Cox- proportional multivariate analysis showed that positive expressions of AGGF1 and VEGF (P=0.043, 0.024) and clinical stage (P=0.035) were significant prognostic factors in overall survival. Conclusions AGGF1 has high expressions in ESCC, and it is closely related to the clinical features and prognosis of ESCC.

分 类 号： [Z1]