作　　者： (李娟）; (王红）; (王守廉）;

机构地区： 710054,西安市第九医院神经内科

出　　处： 《中国医师进修杂志》

摘　　要： 目的 分析成年癫痫合并注意缺陷多动障碍(ADHD)患者临床特征,并探讨癫痫相关自身因素与ADHD患病间的关联性.方法 选择2012年3月至2016年3月82例确诊的成年人癫痫患者(观察组),另选82例健康体检成年人为对照组.对成年人癫痫合并ADHD的发病率及相关危险因素进行统计分析.结果 与对照组比较,观察组ADHD的发生率显著升高[26.8%(22/82)比4.9%(4/82)],差异有统计学意义(χ2=18.672,P<0.01).观察组合并ADHD的检出率以症状性癫痫(8/17)及多病灶痫样放电(6/14)较高(P<0.05).二分类Logistic回归结果提示癫痫的首发年龄可能作为成年人癫痫合并发生ADHD的一个危险因素(B=-0.891,P<0.05).结论成年人癫痫同时合并ADHD的危险性比健康成年人升高,ADHD中注意缺陷型多见;成年人癫痫的病因、痫样放电部位及首次发病年龄与并发ADHD可能密切相关. Objective To investigate the incidence of adult epilepsy patients with attention-deficit hyperactivity disorder (ADHD) and the characteristics of ADHD subtypes, and to explore the correlations between several epilepsy-related factors and ADHD. Methods According to corresponding inclusion criteria and exclusion criteria, 82 adult epilepsy patients from March 2012 to March 2016 were enrolled as study group. Eighty-two healthy adults were enrolled as the control group. Using the Chi-square test and Logistic regression analysis and the other statistical methods, the phenomenon of ADHD in adults with epilepsy and the factors that may contribute to the phenomenon was analyzed. Results The detection rate of ADHD in 82 adult patients with epilepsy was 26.8%(22/82), significantly higher than that in the heathly control group which was 4.9%(4/82),χ2=18.672, P<0.05. Symptomatic epilepsy 8/17 and the electroencephalogram showed multifocal discharge 6/14 had higher detection rate of comorbid ADHD and the difference was statistically significant (P<0.01). The results of binary Logistic regression analysis showed that epilepsy age of onset was possibly an important factor for epilepsy with ADHD (B=-0.891, P<0.05). Conclusions The risk of ADHD in adults with epilepsy is higher than that in the healthy adults and attention-deficit is the common subtype. The etiology, age of onset and electroencephalogram features of adults with epilepsy may be associated with the occurrence of ADHD.

分 类 号： [Z1]