作 者: (杨平平);
机构地区: 中国医科大学附属盛京医院小儿消化内科, 沈阳,110004
出 处: 《国际儿科学杂志》 2017年第7期478-482,共5页
摘 要: 人巨细胞病毒(human cytomegalovirus,HCMV)感染可引起肝脏疾病、肺炎、腹泻病、血小板减少性紫癜、听力障碍等疾病,具有较高的感染率与病死率.pp65(phosphoprotein 65)作为病毒颗粒的主要结构蛋白,与病毒基因表达、宿主免疫逃避及细胞代谢相关.pp65检测目前被认为诊断活动性巨细胞病毒感染的'金标准'之一,且其抗原水平与HCMV感染的临床症状呈正相关性,可用于指导临床'抢先治疗'并改善预后.该文就pp65的蛋白特性、致病机制、诊断方法及其在诊断和预防的应用等方面作一综述. HCMV infection can cause hepatopathy,pneumonia,diarrhea,thrombocytopenic purpura,and sensorineural hearing loss(SNHL),with high morbility and mortality.pp65(phosphoprotein 65),a major constitutive protein of virion,is closely associated with viral gene expression,immune evasion and cell metabolism.pp65 antigenemia level has positive correlation with clinical symptom,which can guide the 'preemptive therapy'and improve prognosis,is considered as one of the 'golden standard methods' of active cytomegalovirus infection.In this paper,the pp65 protein properties,pathogenesis,application in diagnosis and prevention are reviewed.