作　　者： (张婷婷）;

机构地区： 223899,宿迁市第一人民医院

出　　处： 《国际儿科学杂志》 2017年第7期460-463,共4页

摘　　要： 新生儿缺氧缺血性脑病(hypoxic-ischemia encephalopathy,HIE)是一种常见的新生儿神经系统损伤性疾病,目前多采用 '三项支持,三项对症'等传统治疗措施,尚无特异性治疗方法.人脐带间充质干细胞(human umbilical cord mesenchymal stem cell,HUC-MSC)是存在于新生儿脐带组织中的一种多功能干细胞,具有自我更新和多向分化潜能,来源广泛、易于获取、免疫原性低又不涉及伦理问题.其在一定的条件下可分化为神经细胞,分泌神经营养因子,修复脑损伤,促进脑功能恢复.HUC-MSC移植为HIE的治疗提供了一种新的途径. Neonatal hypoxic-ischemic encephalopathy(HIE)is a common disease in neonatal nervous system injury,which often treated by the traditional measures such as three support′s and three symptomatic treatments.Moreover,there is no specific treatment nowadays.The human umbilical cord mesenchymal stem cells(HUC-MSC)are mixture of multifunctional stem cells from neonatal umbilical cord tissues,which has strong abilities of self-renewal and multilineage differentiation potential.HUC-MSC are easy to harvest and have more sources,low immunogenicity and without ethical problems.It can differentiate into neural cells under certain conditions,secrete neurotrophic factors,repair the damaged brain and promote the recovery of cerebral function.Transplantation of HUC-MSC provides a new way for the treatment of HIE.

关 键 词： 人脐带间充质干细胞 新生儿 缺氧缺血性脑病 移植