作　　者： (徐志立）; (梁晗业）; (胡丽萍）; (康廷国）;

机构地区： 辽宁中医药大学,辽宁大连116600

出　　处： 《现代生物医学进展》 2017年第24期4631-4634,共4页

摘　　要： 目的:考察五味子甲素对溃疡性结肠炎(ulcerative colitis,UC)小鼠血液流变性及凝血功能的影响。方法:以三硝基苯磺酸(TNBS)灌肠制备溃疡性结肠炎小鼠模型,UC小鼠随机分为模型组、阳性对照组及五味子甲素高、中、低剂量组(80,40,20mg/kg),同时设立正常对照组,每组10只。灌胃给药,正常组、模型组分别给予等体积蒸馏水,阳性对照组给予500 mg/kg柳氮磺吡啶(SASP),连续给药14 d。观察五味子甲素对UC小鼠全血黏度及凝血功能的影响。结果:与UC模型组小鼠比较,五味子甲素可显著降低UC小鼠全血黏度(P<0.05),延长出血时间(bleeding time,BT)(P<0.01)及凝血时间(clotting time,CT)(P<0.05),其中甲素高剂量组作用最强,与SASP阳性对照组相当,并呈剂量依赖性。结论:五味子甲素可改善UC小鼠血液流变性及凝血功能,此作用有利于UC溃疡黏膜的修复与疾病的治疗。 Objective：To observe the effects of Deoxyschisandrin on hemorrheology and coagulation function in ulcerative colitis （UC）mice.Methods：Trinitrobenzenesulfonic acid （TNBS）induced UC mice model was prepared.And then UC mice were randomly divided into model group,positive control group,high,medium,and low dose groups of deoxyschisandrin （80,40,20mg/kg）,and in addition,a normal control group was set up.There were 10 mice in each group respectively.UC mice were intragastricly administrated with different concentration of deoxyschisandrin in medication group,or with equal volume distilled water in normal group or model group,respectively.The blood viscosity was determined by blood rheometer,and the bleeding time （BT）and the clotting time （CT）were also observed through the methods of tail cutting and blood coagulation in glass plates accordingly.Results：Compared with model group,the BT （P ＜ 0.01）and CT （P ＜ 0.05）were significantly prolonged,and the blood viscosity was decreased obviously （P ＜ 0.05） in UC mice after administrated with different concentration deoxyschisandfin for 14 days.And the effects in high dose group were strongest and similar to those in the positive group.Conclusions：Deoxyschisandrin can improve hemorrheology and coagulation function in UC mice.

关 键 词： 五味子甲素 溃疡性结肠炎 血液流变性 凝血功能