作　　者： (李媛媛）; (陆宇）;

机构地区： 首都医科大学附属北京胸科医院耐药结核病研究北京市重点实验室北京市结核病胸部肿瘤研究所药物研究室,101149

出　　处： 《中国防痨杂志》 2017年第9期1014-1017,共4页

摘　　要： 在当前全球结核病防治形势依然严峻、传统抗结核药物对耐药结核病治疗作用有限的情况下,抗结核新药的发现成为迫切关注的问题.而动物模型对药效学的评价是新药研发的关键步骤,是抗结核新药临床应用的有力支持.作者主要从动物模型的种类、特点等方面介绍常见动物模型在新型抗结核药物药效学评价中的应用,进一步加深基础工作研究者对各种动物模型的了解,有利于选择及建立合适的动物模型以满足研究的需求. The global situation of tuberculosis prevention and control is still grim, and the efficacy of conventional anti-tuberculosis drugs for the treatment of drug-resistant tuberculosis is limited.In these cases, it is an urgent concern to discover new anti-tuberculosis drugs.The use of animal models for the pharmacodynamic evaluation is a key step in the new drug research and development and is a powerful support of anti-tuberculosis drugs for clinical application.In order to deepen the understanding of a variety of animal models of the basic researchers, the author introduces the common animal models in the application of pharmacodynamic evaluation of new anti-tuberculosis drugs from the types and characteristics of animal models.It is helpful to select and establish a suitable animal model to meet the needs of research.

关 键 词： 结核 抗结核药 动物模型 药物评价 临床前药代动力学 综述