作　　者： (刘慧君）; (丁艳芳）; (马丙乾）;

机构地区： 濮阳市第五人民医院检验科,河南濮阳457000

出　　处： 《中国医院用药评价与分析》 2017年第8期1065-1067,共3页

摘　　要： 目的:探讨诺氟沙星联合常规疗法对肺结核患者血清可溶性凋亡相关因子及其配体水平的影响。方法:选取2014年6月—2016年3月濮阳市第五人民医院收治的肺结核患者90例作为研究对象,按随机数字表法分为观察组和对照组,每组45例。对照组患者给予常规化疗,观察组患者在对照组的基础上加用诺氟沙星胶囊1次0.4 g、1日1次。两组患者均治疗3个月。观察两组患者的临床疗效、痰液结核分枝杆菌转阴情况、血清可溶性凋亡相关因子及其配体水平。结果:观察组患者的总有效率为95.56%(43/45),明显高于对照组的75.56%(34/45),差异有统计学意义(P<0.05)。治疗后,观察组患者痰液结核分枝杆菌阴转率为87.50%(21/24),明显高于对照组的63.64%(14/22),差异有统计学意义(P<0.05);观察组患者可溶性凋亡相关因子水平明显低于对照组,可溶性凋亡相关因子配体水平明显高于对照组,差异均有统计学意义(P<0.05)。治疗前后,两组痰液结核分枝杆菌转阴患者可溶性凋亡相关因子水平明显低于同组未转阴患者,可溶性凋亡相关因子配体水平明显高于同组未转阴患者,差异均有统计学意义(P<0.05)。结论:诺氟沙星联合常规疗法治疗肺结核的疗效显著,可降低患者血清可溶性凋亡相关因子水平,升高可溶性凋亡相关因子配体水平。 OBJECTIVE： To probe into the effects of norfloxacin combined with conventional treatment on s Fas and s Fas L Level of tuberculosis patients. METHODS： 90 tuberculosis patients admitted into Puyang the Fifth People＇s Hospital from Jun. 2014 to Mar. 2016 were extracted to be divided into observation group and control group via the random number table,with 45 cases in each. The control group was given conventional chemotherapy,while the observation group additionally received Norfloxacin capsules 0. 4 g based on the control group,once a day. The treatment was lat for 3 months in two groups. The clinical efficacy,sputum negative conversion rate and the level of s Fas and s Fas L of two groups were observed. RESULTS： The total effective rate of observation group was 95. 56%（ 43/45）,significantly higher than that of control group [75. 56%（ 34/45） ],with statistically significant difference（ P〈0. 05）. After treatment,the sputum negative conversion rate of observation group was 87. 50%（ 21/24）,significantly higher than that of control group [63. 64%（ 14/22） ],with statistically significant difference（ P〈0. 05）.After treatment,the s Fas level of observation group was significant lower than that of control group,yet the level of s Fas L was higher than that of control group,with statistically significant difference（ P〈0. 05）. Before and after treatment,the s Fas level in patients with sputum negative conversion was significantly lower than that of patients without any sputum negative conversion,yet the level of s Fas L was significantly higher than that of patients without any sputum negative conversion,with statistically significant difference（ P〈0. 05）. CONCLUSIONS： The efficacy of norfloxacin combined with conventional treatment in treatment of tuberculosis is remarkable,which can reduce level of s Fas in plasma and increase the level of s Fas L.

关 键 词： 肺结核 诺氟沙星 可溶性凋亡相关因子 可溶性凋亡相关因子配体