作　　者： (王子妤）; (郑冉）; (马明君）; (苑志博）; (梁洋）;

机构地区： 东北林业大学生命科学学院,哈尔滨150040

出　　处： 《中国细胞生物学学报》 2017年第8期1118-1123,共6页

摘　　要： 外泌体(exosomes)是一种由活细胞分泌并释放到胞外环境中、大小在60~100 nm的运输膜泡。外泌体以其天然的物质转运特性、相对较小的分子结构和优良的生物相容性,可递送化学药物、蛋白质及肽配基和基因药物等多种药物,在药物载体的领域具有巨大的潜力。该文重点介绍了外泌体运载多种药物的不同应用及靶向给药中三种主要策略和应用以及其他靶向给药的方向及应用,阐述了外泌体作为药物载体的优势和挑战。 Exosomes are 60-100 nm extracellular membrane vesicles from living cell by receptor-mediated endocytosis, macropinocytosis, or phagocytosis. Exosomes can be treated as safe drug delivery vehicles due to the fact that it involves in intercellular communication by attached to target cells via its surface molecules. As theranostic nanosystems, exosomes are small and highly immunological compatible which can deliver versatile cargos, such as the chemical molecules, proteins, generic-drugs. In this review, we summarize the recent progress in using exosomes for therapeutic, especially for target therapy, and discuss the advantages of exosomes as potential drug delivery vehicles and the potential challenges.

关 键 词： 外泌体 药物载体 靶向给药