作　　者： (侯小明）; (刘小军）; (令晓玲）; (马守成）; (杨丽平）; (赵达）;

机构地区： 兰州大学第一临床医学院,甘肃兰州730000 兰州大学第一医院肿瘤内科,甘肃兰州730000 兰州大学第一医院甘肃省生物治疗与再生医学重点实验室,甘肃兰州730000

出　　处： 《现代肿瘤医学》 2017年第19期3164-3167,共4页

摘　　要： 目的:观察盐酸羟考酮缓释片联合吗啡片12小时或24小时滴定治疗中、重度癌痛的疗效及不良反应。方法:选择120例中、重度癌痛患者,根据患者入院顺序单双号,将患者分为羟考酮缓释片联合吗啡片12小时滴定组60例和24小时滴定组60例。对两组的镇痛疗效及不良反应进行观察及评估。结果:与24小时滴定组比较,12小时滴定组的24小时镇痛缓解率明显提高;疼痛达稳态时间明显缩短,差异具有统计学意义(P<0.05);而两组滴定平均滴定剂量、镇痛起效时间及主要毒副反应的发生率相似,差异无统计学意义(P>0.05)。结论:羟考酮缓释片联合吗啡片12小时滴定方案对中、重度癌痛镇痛效果好,不良反应轻,是治疗癌痛的理想选择之一。 Objective ： To observe the efficacy and adverse reactions of oxycodone hydrochloride sustained - release tablets combined with morphine tablets 12 hours or 24 hours titration in the treatment of moderate and severe cancer pain. Methods： 120 patients with moderate or severe cancer pain were divided into two groups ：Oxycodone sustained - release tablet combined with morphine tablet 12 hours：Titration group 60 cases and 24 -hour titration group 60 ca- ses. The analgesic efficacy and side effects were observed and evaluated. Results ： Compared with the 24 - hour titra- tion group,the 24 - hour analgesic response rate of the 12 - hour titration group was significantly improved ; the time of pain steady state was significantly shortened,the difference was statistically significant（P 〈 0.05 ）. The time of onset of analgesia and the incidence of major toxicities were similar, the difference was not statistically significant（P 〉 0.05 ）. Conclusion, Oxycodone sustained - release tablet combined with 12 hours titration scheme of morphine tablet is an ideal choice for the treatment of cancer pain, with good analgesic effect and mild side effect.

关 键 词： 癌痛 羟考酮缓释片 吗啡片 滴定治疗