作　　者： (刘利艳）; (罗刘飞春）; (武乐）; (邱宇安）; (王文红）; (李阿玲）; (郑志难）; (王佳丽）; (唐军华）; (傅永芹）;

机构地区： 江西省肿瘤医院;南昌大学抚州医学院,330029

出　　处： 《实用癌症杂志》 2017年第9期1553-1556,共4页

摘　　要： 目的探讨抗肿瘤药物不良反应发生的特点,以减少抗肿瘤药物不良反应的发生,为临床合理用药提供依据。方法采用系统抽样的方法,收集江西省肿瘤医院2013年1月至2015年12月上报于国家药品不良反应监测中心网络平台的413例不良反应(ADR)报告,分别从患者的性别、年龄、药物类别、所累及器官或系统及临床表现等进行统计、分析。结果 413例ADR中男性242例、女性171例;40岁以上中老年患者居多,占86.92%;原患疾病中呼吸系统肿瘤所占比率最高;铂类药物引发的不良反应发生率最高,占23.73%,主要为恶心、呕吐和腹泻;所累及的器官或系统中,消化系统所占比例最高,达24.09%。结论对抗肿瘤药物不良反应的监测工作应加以重视,做好不良反应的预防及处理,以保证用药安全。 Objective To analyze the characteristics of adverse drug reactions（ ADR） induced by anti-cancer drug,reduce its incidence and provide references for safe use of antineoplastic drugs clinically. Methods 413 cases with ADR of antineoplastic drugs were collected. Age,sex,kinds of drugs,ADR-involved organs or systems and clinical manifestations of patients were analyzed. Results In 413 ADR cases,242 were male and 171 were female,anti-cancer drugs-induced ADR mainly occurred in male. The incidence of ADR occurred in the patients older than 40 was 86. 92%. Digestive system neoplasms had the highest incidence in disease of original. The platinum-induced ADR had the highest incidence（ 23. 73%）,ADR-involved organs or systems mainly affected gastrointestinal system which mainly included nausea,vomiting and diarrhea. Conclusion Great attention should be paid to the work of monitoring ADR induced by anti-cancer drugs and our best should be paid to prevent ADR in order to ensure the safety of drug usage.

关 键 词： 抗肿瘤药物 药物不良反应 合理用药