作　　者： (薛伟红）; (王友春）; (韩宏锋）; (李志宾）; (杨静）;

机构地区： 郑州大学附属洛阳中心医院,471000

出　　处： 《实用癌症杂志》 2017年第9期1489-1493,共5页

摘　　要： 目的研究乙型肝炎病毒感染与原发性肝癌间关联性,并对危险因素探讨。方法慢性乙型肝炎病毒感染患者220例,其中慢性乙肝小三阳64例(小三阳组),慢性乙型肝炎大三阳62例(大三阳组),慢性乙型肝炎肝硬化50例(肝硬化组),乙型肝炎相关原发性肝癌44例(原发性肝癌组)。观察4组乙肝病毒DNA不同含量(采用乙型肝炎病毒检测试剂盒检测)患者分布情况及表达水平;采用PCR扩增方法检测4组患者乙肝病毒DNA含量,采用双抗体夹心酶联免疫吸附试验测定乙肝表面抗原。结果 4组患者乙肝病毒DNA不同含量患者分布比较差异有统计学意义(P<0.05),小三阳组DNA不同含量患者分布与大三阳组、肝硬化组、原发性肝癌组比较,差异有统计学意义(P<0.05)。小三阳组乙肝病毒DNA表达水平高于大三阳组、肝硬化组和原发性肝癌组,差异有统计学意义(P<0.05),大三阳组乙肝病毒DNA表达水平高于肝硬化组,差异有统计学意义(q=3.884,P<0.05)。4组患者乙肝表面抗原水平差异有统计学意义(P<0.05),小三阳组与大三阳、肝硬化组和原发性肝癌组比较,差异有统计学意义(P<0.05),大三阳组与肝硬化组和原发性肝癌组比较,差异有统计学意义(P<0.05)。原发性肝癌组5~15年、>15年吸烟率,>15年饮酒率高于肝硬化组,不良饮食、e抗原阳性发生率高于肝硬化组,差异有统计学意义(P<0.05)。结论慢性乙肝小三阳、大三阳、肝硬化、原发性肝癌中,乙型肝炎病毒DNA水平和乙肝表面抗原呈下降趋势,长期吸烟、饮酒,不良饮食习惯和e抗原阳性是原发性肝癌发病的危险因素。 Objective To study the relationship between hepatitis B virus infection and primary liver cancer,and to explore the risk factors. Methods 220 patients with chronic hepatitis B virus infection were selected,including 64 cases of chronic hepatitis（ positive group）,62 cases of chronic hepatitis B HBe Ag（ HBe Ag positive group）,50 cases of chronic hepatitis B cirrhosis（ cirrhosis group）,44 cases of hepatitis B primary hepatocellular carcinoma（ PHC）. PCR amplification method was used to detect hepatitis B virus DNA content of the 4 groups,and DAS-ELISA was used to detect hepatitis B surface antigen. Results Distribution of patients with different hepatitis B virus DNA content of the 4 groups had statistically significant difference（ P〈0. 05）,Distribution of patients with different hepatitis B virus DNA content of positive group and the other groups had statistically significant difference（ P〈0. 05）. Hepatitis B virus DNA expression level of positive group was higher than the other groups,the difference was statistically significant（ P〈0. 05）,the expression level of hepatitis B virus DNA of HBe Ag positive group was higher than cirrhosis group,the difference was statistically significant（ q = 3. 884,P〈0. 05）. The difference was statistically significant in hepatitis B surface antigen levels among the 4 groups（ P〈0. 05）,positive group and the other groups had statistically significant difference（ P〈0. 05）,HBe Ag positive group and liver cirrhosis group and HCC group had statistically significant difference（ P〈0. 05）. The rate of smoking was 5 years and 15 years in the primary liver cancer group,and the drinking rate was higher in the 15 group than that in the liver cirrhosis group. The incidence of adverse diet and e antigen was higher than that of the liver cirrhosis group,the difference was statistically significant（ P〈0. 05）. Conclusion In chronic hepatitis,HBe Ag,cirrhosis,hepatocellular carcinoma,hepatitis B virus DNA and hepatitis B surface antigen gr

关 键 词： 乙型肝炎病毒 肝肿瘤 危险因素