作　　者： (牟宗阳）; (刘兴德）; (殷雪娇）; (陈诗婷）; (罗惠兰）;

机构地区： 贵州医科大学,贵州贵阳550004

出　　处： 《贵州医科大学学报》 2017年第8期876-878,892,共4页

摘　　要： 目的:探讨飞行员血清基质金属蛋白酶9(MMP-9)与冠状动脉粥样硬化的关系。方法:选取确诊有动脉粥样硬化的飞行员70例(飞行员动脉粥样硬化组)、动脉粥样硬化普通人210例(普通人动脉粥样硬化组)、健康飞行员120例(飞行员正常组)和普通健康体检者150例(普通人正常组),测定被检查各组血清MMP-9水平。结果:飞行员动脉粥样硬化组血清MMP-9水平明显高于飞行员正常组(t=4.118,P<0.05),飞行员动脉粥样硬化组血清MMP-9与普通人动脉粥样硬化组比较,差异无统计学意义(t=2.649,P>0.05);普通人动脉粥样硬化组血清MMP-9高于普通人正常组,差异有统计学意义(t=3.055,P<0.05)。结论:MMP-9与冠状动脉粥样硬化有关,飞行因素可能不是影响MMP-9表达的一个危险因素。 Objective： To investigate relationship between serum levels of matrix metalloproteinase-9（ MMP-9） and coronary atherosclerosis in pilots. Methods： This study recruited pilots with coronary atherosclerosis（ 70 cases）,ordinary patients with coronary atherosclerosis（ 210 cases）,healthy pilots（ 120 cases）,and healthy subjects（ 150 cases）. Serum levels of MMP-9 were detected and compared among the 4 groups. Results： Serum level of MMP-9 in pilots with coronary atherosclerosis was significantly higher than that of healthy pilots（ t = 4. 118,P〈0. 05）. No significant difference was found in serum level of MMP-9 between pilots with coronary atherosclerosis and ordinary patients with coronary atherosclerosis（ t = 2. 649,P〉0. 05）. Serum level of MMP-9 in ordinary patients with coronary atherosclerosis was significantly higher than that of healthy subjects（ t = 3. 055,P〈0. 05）. Conclusion：MMP-9 is associated with the development and progression of coronary atherosclerosis,and the flight factor of the pilot may not affect the expression of MMP-9.

关 键 词： 基质金属蛋白酶 冠状动脉疾病 动脉粥样硬化 血清 飞行员