作　　者： (郭英杰）; (宋文）; (李晓宇）; (荆雪）; (丁雪丽）; (张鹏）; (田字彬）;

机构地区： 青岛大学附属医院消化内科,山东青岛266000

出　　处： 《中华胰腺病杂志》 2017年第4期231-237,共7页

摘　　要： 目的总结我国近10年复发性急性胰腺炎（RAP）的病因及临床特征。方法以急性胰腺炎（AP）、复发、病因为检索词，检索2000年1月至2016年12月Pubmed、Medline、EMbase、中国知网、万方及维普数据库收录的文献。应用RevMan5．3软件进行Meta分析。结果16篇文献共3980例患者（复发组1231例，初发组2749例）纳人研究。患者年龄、性别与AP复发无相关性；胆源性、酒精性、饮食不当等因素与AP复发相关，但不是影响RAP的因素；复发组高血脂症病因占17．00％，初发组占10．20％，两组间差异有统计学意义（P=0．002），高血脂症是影响AP复发的重要危险因素。初发组与复发组患者中SAP分别占16．83％和24．13％，并发症发生率分别为11．43％、15．13％，黄疸出现率分别为28．20％、32．53％，复发组均显著高于初发组，差异均有统计学意义（P值均〈0．05）。结论高脂血症为我国AP复发的重要危险因素，RAP患者更易出现并发症及黄疸，更易发展为SAP。 Objective To summarize the etiology and clinical features of recurrent acute pancreatitis （RAP） in the recent 10 years in China. Methods Pubmed, Medline, EMbase, CNKI, Wan fang and VIP database were searched for relevant articles published from January 2001 to December 2016 using ＂Pancreatitis＂, ＂Recurrence＂ and ＂Etiology＂ as term index words. Meta analysis was conducted by RevManS. 3 software. Results A total of 16 studies involving 3 980 patients （ RAP n = 1 231, AP n = 2 749） were included. The age and sex were not correlated with AP recurrence. Biliary diseases, alcohol, inappropriate diets were associated with AP recurrence, but these were not the factors influencing RAP. Hyperlipidemia was responsible for the occurrence of pancreatitis in 17.00% of RAP and 10.20% of AP, with statistically significant difference （P =0.002 ）. Hyperlipidemia was an important risk factor influencing AP relapse. The percentage of SAP in AP and RAP patients was 16.83% and 24.13%, respectively, and the complication rate was 11.43% and 15.13%, and the percentage of jaundice was 28.20% and 32.53%. Those in RAP were higher than those in AP, and the differences were statistically significant （ all P 〈 0.05 ）. Conclusions Hyperlipidemia was the predominant risk factor for RAP in China, and th~ patients with RAP tend to progress into SAP, and have jaundice and complications.

关 键 词： 胰腺炎 复发 高脂血症 分析