作　　者： (王颖林）; (郭向阳）;

机构地区： 同济大学附属东方医院麻醉科,上海200120

出　　处： 《药学进展》 2017年第8期579-582,共4页

摘　　要： 恶性高热是挥发性麻醉药和去极化肌肉松弛药诱发的、危及生命的高代谢状态,孤儿药——丹曲林钠是目前治疗恶性高热的唯一特效药物,但中国大陆尚未引进及生产该药。随着我国恶性高热病例的不断增加,丹曲林钠缺失问题应予以重视。重点介绍恶性高热的发病机制及其治疗药丹曲林钠在国内外的应用情况,以期为恶性高热及相关治疗药物的研发提供一定的参考。 Human malignant hyperthermia （MH） is a life-threatening genetic sensitivity of skeletal muscles to volatile anaesthetics and depolarizing neuromuscular blocking drugs occurring during or after anaesthesia. Dantrolene is a skeletal muscle relaxant that has been granted Orphan Drug designation as the only currently available drug for specific and effective therapy of MH. However, this drug hasn＇t been licensed and produced in China's Mainland. With increasing cases of MH reported in China, the lack of dantrolene sodium should be taken seriously. This review mainly introduced the mechanism of MH and the current use of dantrolene in China and abroad, so as to provide references for researches of MH and related drugs.

关 键 词： 丹曲林钠 恶性高热 肌肉松弛剂