作　　者： (熊英琼）; (梅竹君）; (章伟）; (屈新辉）; (吴晓牧）;

机构地区： 南昌大学研究生院,南昌330006

出　　处： 《中国免疫学杂志》 2017年第9期1371-1374,共4页

摘　　要： 目的:探讨血清抗幽门螺旋杆菌抗体(HP-Ig G)和抗AQP4抗体在多发性硬化(MS)、视神经脊髓炎(NMO)中的相关性。方法:对33例MS患者、7例NMO患者和35例健康体检者采用间接酶联免疫吸附法(ELISA法)检测血清中抗HP的Ig G抗体,采用细胞间接免疫荧光法(CBA)检测血清标本抗AQP4抗体;分析MS、NMO患者中HP-Ig G及抗AQP4抗体的阳性率,并对比抗AQP4抗体阳性与抗AQP4抗体阴性患者间HP-Ig G阳性率的差别。结果:MS组、NMO组和正常对照组血清中抗血清HP-IgG抗体阳性率分别为69.70%、85.71%、42.86%,差别有统计学意义(P<0.05),其中MS组、NMO组与正常对照组血清中抗HP-Ig G抗体阳性率差别均有统计学意义(P<0.05);但MS组与NMO组血清中抗HP-Ig G抗体阳性率差别无统计学意义(P>0.05)。MS组、NMO组和正常对照组血清中抗AQP4抗体阳性率分别为4.2%、85.71%、0%,差别有统计学意义(P<0.05)。MS组和NMO患者组中抗AQP4抗体阳性患者与抗AQP4抗体阴性患者抗HP-IgG抗体阳性率分别为72.73%、79.31%,差别无统计学意义(P>0.05)。结论:HP感染是引起MS及NMO疾病发生的危险因素,而与MS及NMO患者是否含有抗AQP4抗体无关。 Objective To investigate the relationship between anti-Helicobacter pylori antibody（Hp-IgG）and anti-aquaporin 4 antibody which are in neuromyelitis optica（NMO）and multiple sclerosis（ MS）. Methods： Serum specimens were collected from the 33 patients with MS,7 patients with NMO,and 35 health examination cases. Hp-IgG were detected by enzyme-linked immunosorbent assasy and anti-aquaporin 4 antibody were detected by cell based assay respectively. The positive rate of Hp-IgG and anti-aquaporin 4 antibody were analyzed,and the difference of Hp-IgG positive rate was compared between patients with Hp-IgG positive and negative. Results： Serum Hp-IgG positive rate of MS,NMO and normal control groups were 69. 70% , 85. 71% and 42. 86% respectively with a significant statistically difference of Hp-IgG（P〈0. 05）. Positive rate of serum anti HP-IgG antibody in MS group,NMO group and normal control were significantly different（P〈0.05）;but there was no statistical significant difference of anti HP-IgG antibody positive rate between MS group and NMO group（ P〉0. 05）. Serum anti AQP4 antibody positive rate of MS,NMO and normal control groups were 4. 2%, 85. 71% and 0% respectively with a significant statistically difference of anti AQP4 antibody（ P〈0. 05）. The positive rates of anti HP- IgG which were in MS patients and NMO patients with positive anti AQP4 antibody were 72. 73% , the positive rates of anti HP-IgG which were in MS patients and NMO patients with negative anti AQP4 antibody were 79. 31 % , the difference was not statistically significant（P〉0. 05）. Conclusion： HP infection is a risk factor for the occurrence of MS and NMO, but not associated with MS and NMO patients with anti AQP4 antibodies.

关 键 词： 多发性硬化 视神经脊髓炎 抗幽门螺旋杆菌抗体 抗 抗体