作　　者： (李旭卉）; (吴习习）; (张凯）; (罗海霞）; (李敏）;

机构地区： 宁夏大学生命科学学院/西部特色生物资源保护与利用教育部重点实验室（宁夏大学）,宁夏银川750021

出　　处： 《动物医学进展》 2017年第9期109-114,共6页

摘　　要： 线粒体自噬是选择性自噬的一种,线粒体通过自噬途径被选择性清除。线粒体自噬对于细胞内环境稳定来说十分关键,细胞利用线粒体自噬机制消除功能障碍的线粒体或减少线粒体数量等来适应应激,维持胞内内环境的稳定。因此,对于线粒体自噬的分子机制以及生理作用的研究具有重要的生物学意义。细胞可通过多种分子机制介导线粒体自噬,如PINK1/Parkin、Nix和FUNDC1途径。线粒体自噬调控机制的失调或障碍与人类多种疾病的发病密切相关,有研究发现在多种癌症中存在着不同水平的线粒体自噬,包括直肠癌、肺癌、乳腺癌等,从而也反映了线粒体自噬与癌症的密切关系。论文介绍了线粒体自噬作用和过程的最新研究进展,并着重总结自噬与癌症的关系。 Mitophagy, the selective engulfment and clearance of mitochondria, is essential for the homeo-stasis of a healthy network of functioning mitochondria. Cells use mitophagy to eliminate dysfunctional mi-tochondria or reduce the number of mitochondria to adapt to stress and maintain intracellular environmen-tal stability. At present, mitophagy can be mediated by a variety of molecular mechanisms, such as PINKl/Parkin,BNIP3 ,Nix and FUNDC1 pathways. In recent studies,it is reported that there exists mito-phagy in a variety of cancer,including lung cancer, breast cancer and so on. In this review,we briefly sum-marized recent progress in understanding the function and process of mitophagy. In particular, we focused on studies that reveal the relationship between mitophagy and cancer.

关 键 词： 线粒体自噬 癌症