作　　者： (陈光生）; (林伯昌）; (朱伟明）; (姚带章）;

机构地区： 博罗县人民医院,广东惠州516100

出　　处： 《现代药物与临床》 2017年第8期1429-1432,共4页

摘　　要： 目的探讨丁苯酞软胶囊治疗急性脑梗死的临床疗效。方法选取2013年6月—2016年6月博罗县人民医院收治的急性脑梗死患者104例,所有患者采用随机数字表法分为对照组和治疗组,每组各52例。对照组给予常规治疗,包括脱水降颅内压、服用阿司匹林抗凝、阿替普酶或尿激酶静脉溶栓、依达拉奉改善脑循环、服用脑保护剂等,并根据患者情况进行原发病对症治疗。治疗组在对照组基础上口服丁苯酞软胶囊,0.2 g/次,2次/d。两组患者均连续治疗2周。观察两组的临床疗效,比较美国国立卫生研究院卒中量表(NHISS)评分、Barthel指数、血液流变学、颈总动脉后壁内中膜厚度(IMT)和颈总动脉血流阻力指数(RI)。结果治疗后,对照组和治疗组的总有效率分别为69.23%、90.38%,两组比较差异具有统计学意义(P<0.05)。治疗后,两组全血黏度、血浆黏度、纤维蛋白原水平均显著降低,而血细胞比容显著升高,同组治疗前后比较差异有统计学意义(P<0.05);且治疗组这些观察指标的改善程度明显优于对照组,两组比较差异具有统计学意义(P<0.05)。治疗后,两组NIHSS评分显著下降,而Barthel指数显著上升,同组治疗前后比较差异有统计学意义(P<0.05);且治疗组这些观察指标的改善程度明显优于对照组,两组比较差异具有统计学意义(P<0.05)。治疗后,两组IMT和RI均显著降低,同组治疗前后比较差异有统计学意义(P<0.05);且治疗组这些观察指标明显低于对照组,两组比较差异具有统计学意义(P<0.05)。结论丁苯酞软胶囊治疗急性脑梗死具有较好的临床疗效,可显著改善神经功能缺损情况,提升生活质量,降低血液黏稠度,改善颈动脉粥样硬化,具有一定的临床推广应用价值。 Objective To investigate the clinical effect of Butylphthalide Soft Capsules in treatment of acute cerebral infarction. Methods Patients （104 cases） with acute cerebral infarction in Boluo County People＇s Hospital from June 2013 to June 2016 were randomly divided into control and treatment groups, and each group had 52 cases. Patients in the control group were given routine treatment, including dehydration to reduce intracranial pressure, using aspirin anticoagulant, intravenous thrombolysis with urokinase or alteplase, improving cerebral circulation with edaravone, taking brain protective agent, and treatment of symptomatic primary disease according to patients＇conditions. Patients in the treatment group were po administered with Butylphthalide Soft Capsules on the basis of the control group, 0.2 g/time, twice daily. Patients in two groups were treated for 2 weeks. After treatment, the clinical efficacies were evaluated, and NHISS score, Barthel index, blood rheology, IMT, and RI in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 69.23% and 90.38%, respectively, and there was difference between two groups （P 〈 0.05）. After treatment, the levels of whole blood viscosity, plasma viscosity, and fibrinogen in two groups were significantly decreased, but the hematocrit in two groups was significantly increased, and the difference was statistically significant in the same group （P 〈 0.05）. And the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups （P 〈 0.05）. After treatment, the NIHSS scores in two groups were significantly decreased, but the Barthel indexes in two groups were significantly increased, and the difference was statistically significant in the same group （P 〈 0.05）. And the observational indexes in the treatment group were significantly better than those in the control group, with significant difference betw

关 键 词： 丁苯酞软胶囊 急性脑梗死 血液流变学 评分 指数 颈总动脉后壁内中膜厚度 颈总动脉血流阻力指数