作　　者： (刘毅）; (卓琳）; (朱蓓）; (何明喻）; (许阳）; (王彤彤）; (胡斌）; (徐继承）;

机构地区： 徐州医科大学公共卫生学院,江苏徐州221004

出　　处： 《中国当代儿科杂志》 2017年第9期994-998,共5页

摘　　要： 目的探讨妊娠期抑郁症与新生儿低出生体重的关系,为预防新生儿低出生体重提供科学依据。方法系统收集研究妊娠期抑郁症与低出生体重关系的队列研究文献,进行Meta分析,由两名研究人员独立地提取数据,按照NOS量表对纳入文献进行质量评价,采用Egger's检验评估发表偏倚。结果共纳入12篇队列研究文献,涉及37 192个样本。Meta分析结果表明:妊娠期抑郁症与新生儿低出生体重有关(Z=2.08,P=0.038),妊娠期抑郁的孕母其新生儿发生低出生体重的风险更高(RR=1.303,95%CI:1.015~1.672)。敏感性分析结果表明该Meta分析结果稳定可靠,Egger's检验结果表明无发表偏倚。结论妊娠期抑郁症可能是新生儿低出生体重的危险因素。 Objective To study the association between depression during pregnancy and low birth weight in neonates, and to provide a scientific basis for the prevention of low birth weight. Methods Cohort studies on the association between depression during pregnancy and low birth weight were collected and a Meta analysis was performed. Data were extracted independently by two investigators, and quality assessment was performed according to Newcastle-Ottawa Scale. The Egger＇s test was used to evaluate publication bias. Results A total of 12 cohort studies with 37 192 samples were included. The results of the Meta analysis showed that depression during pregnancy was associated with low birth weight（Z=2.08, P=0.038）, and the neonates whose mothers had depression during pregnancy tended to have a high risk of low birth weight（RR=1.303, 95%CI： 1.015-1.672）. The sensitivity analysis showed that the results of this Meta analysis were stable and reliable, and the Egger＇s test showed no publication bias. Conclusions Depression during pregnancy may be a risk factor for low birth weight in neonates.

关 键 词： 妊娠期抑郁症 低出生体重 分析 新生儿