作　　者： (高松）; (郝继辉）;

机构地区： 天津医科大学肿瘤医院胰腺肿瘤科、国家肿瘤临床医学研究中心、天津市肿瘤防治重点实验室、天津市恶性肿瘤临床医学研究中心,天津市300060

出　　处： 《中国肿瘤临床》 2017年第16期826-830,共5页

摘　　要： 胰岛素样生长因子结合蛋白(insulin-like growth factor binding protein,IGFBPs)在机体的生长发育和增殖凋亡中发挥重要作用。该家族中,IGFBP2具有调控胰岛素样生长因子(insulin-like growth factor,IGF)的功能。IGFBP2通过自身独特的结构,不仅能与IGF结合,还与细胞外基质相互作用,进而激活下游相关信号通路,在肿瘤的生物学行为中发挥重要的作用。IGFBP2在多种恶性肿瘤中特异性高表达且与患者治疗和预后相关,具备作为诊断标记物和治疗靶点的潜力。本文结合国内外文献,就IGFBP2在肿瘤恶性生物学行为和临床应用中的研究进展进行综述。 Insulin-like growth factor binding proteins（IGFBPs） are crucial to cell growth,development,proliferation,and apoptosis in humans.Among IGFBPs,IGFBP2 is recognized as a regulator of insulin-like growth factor（IGF）.Besides binding with IGF,IGFBP2 also interacts with extracellular matrix through its specific structure.IGFBP2 promotes the malignant phenotype of tumor by activating several important intracellular signal pathways.IGFBP2 is specifically overexpressed in several malignant tumors,and this overexpression is correlated with patient prognosis.IGFBP2 is regarded as a potential biomarker and a therapeutic target.This review briefly summarizes the latest progress of research on the role of IGFBP2 in tumor malignant biological behavior and its clinical application.

关 键 词： 胰岛素样生长因子结合蛋白 肿瘤 恶性进展 转移