作　　者： (卢俊慧）; (徐浩）; (宋远圆）; (殷松楼）;

机构地区： 徐州医科大学研究生院,江苏徐州223000

出　　处： 《临床肺科杂志》 2017年第10期1806-1808,1812,共4页

摘　　要： 目的探讨人血清Ⅱ型肺泡细胞表面抗原(KL-6)对结缔组织病相关间质性肺病(CTD-ILD)诊断的作用。方法选取117例结缔组织病(CTD)患者,根据有无合并间质性肺病(ILD)分为CTD-ILD组67例,CTD组(未合并ILD)50例,同时收集肺部感染者61例,正常对照组60例,ELISA法测定各组血清KL-6水平,比较组间差异。CTD-ILD组行肺功能及胸部HRCT检查,分析血清KL-6水平和DLCo及HRCT评分的相关性。结果 CTD-ILD组KL-6水平(1383.41±1169.69U/m L)较CTD组(791.96±655.64U/m L)、肺部感染组(692.22±506.88U/m L)、正常人群组(502.87±486.32U/m L)高,差异有统计学意义(F=12.233,P<0.05),而CTD组、肺部感染组及正常对照组之间差异无统计学意义(P>0.05)。CTD-ILD组血清KL-6水平和HRCT评分呈正相关关系(r=0.861,P<0.001),KL-6和DLCo呈负相关相关关系(r=-0.41,P<0.05)。结论血清KL-6在CTD-ILD患者明显升高,有助于CTD-ILD的诊断和鉴别肺部感染。KL-6水平和HRCT评分呈正相关关系,和DLCo呈负相关关系,提示KL-6可作为CTD-ILD病情评估的指标。 Objective To investigate the value of serum Krebs von den Lungen-6 （ KL-6 ） in the diagnosis and evaluation of the severity of connective tissue disease-interstitial lung disease （CTD-ILD）. Methods 117 con-nective tissue disease （CTD） patients were selected and divided into the CTD-ILD group （ n = 6 7 ） and the CTD group （n =50） according to with interstitial lung disease or not. At the same time, it selected 61 cases of pulmonary infection and 60 cases of normal physical examination. The serum KL-6 levels were measured by enzyme linked im-munosorbent assay （ELISA） method, and were compared among the groups. For the CTD-ILD group, carbon monox-ide diffusing capacity （ DLCo） and lung high resolution computer test （ HRCT） were also studied. Results The ser-um KL^6 level in the CTD-ILD group （383. 41 ± 1 169. 69 U/mL） was much higher than in the CTD group （791. 96 ±655. 64U/mL） （F = 12. 233 , P 〈0. 0 5 ） . There was no significant difference in other three groups （P 〉 0. 0 5 ） . In the CTD-ILD group, the level of serum KL-6 was positively correlated with pulmonary HRCT scores （r = 0. 861,P 〈 0. 01） , and was negatively correlated with DLCo （ r = - 0 . 41, P 〈 0 . 0 5 ） . Conclusion In the patients of CTD- ILD, the level of serum KL-6 increases significantly, and it is helpful in the diagnosis and differential diagnosis of pulmonary infection in CTD-ILD. KL-6 level and HRCT score are positively correlated, and DLCo is negatively corre-lated, which suggests that KL-6 can be used as an indicator of CTD-ILD disease assessment.

关 键 词： 结缔组织病 间质性肺病 诊断