作　　者： (彭靓）; (叶萍）; (叶秀仙）; (谢晓英）;

机构地区： 赣南医学院2014级硕士研究生,江西赣州341000

出　　处： 《赣南医学院学报》 2017年第4期636-641,共6页

摘　　要： 卵巢癌是女性常见恶性肿瘤之一,其发病率和死亡率近年来居高不下,为改善患者预后,有必要寻找有效的早期诊断和治疗方法。自噬和microRNAs是近年来研究的热点,自噬参与恶性肿瘤的发病机制,靶向自噬途径可作为一种新的抗癌治疗手段,而microRNAs调控自噬相关过程,揭示自噬相关microRNAs的作用机制十分重要,尤其在卵巢癌的诊断和分子治疗方面。本文综述了microRNAs通过调控卵巢癌自噬水平对卵巢癌的发病机制和病程进展的潜在影响。 Ovarian cancer is one of the most common malignancies in women with high morbidity and mortality in recent years. It is necessary to search for effective methods for early diagnosis and treatment to improve the prognosis. Nowadays research focuses on autophagy and microRNAs,which are involved in the pathogenesis of malignances. Targeting autophagy pathway is being under evaluation as a new anti-cancer therapy. MicroRNAs regulates autophagy related processes.Therefore,it is important to reveal the mechanism of autophagy-related microRNAs,especially in the diagnosis and molecular treatment of ovarian cancer. This review focuses on the potential role of miRNAs regulating autophagy in pathogenesis and progression of ovarian cancer.

关 键 词： 自噬 卵巢癌