作　　者： (周国军）; (邱雪）; (钟玲）;

机构地区： 深圳宝安区中心医院臣田社区健康服务中心,广东518102

出　　处： 《社区医学杂志》 2017年第15期10-12,共3页

摘　　要： 目的观察复方丹参滴丸联合西药治疗急性缺血性脑卒中患者的临床治疗效果。方法选取2014年1月—2017年1月住院治疗的急性缺血性卒中患者200例,随机分为实验组与对照组各100例。对照组均给予以常规对症治疗,实验组在对照组的基础上给予复方丹参滴丸治疗,10丸/次,3次/d。4周为1个疗程,治疗2个疗程。比较这两组血小板参数、血脂参数变化情况及临床疗效,并观察不良反应发生情况。计量资料比较采用t检验,计数资料比较采用χ2检验,P<0.05为差异有统计学意义。结果治疗后,实验组血小板最大聚集率、血浆血栓素B2水平、平均血小板体积、甘油三酯(TG)、总胆固醇(TC)与低密度酯蛋白(LDL-C)[(31.9±8.4)%、(92.6±21.5)ng/L、(44.3±8.1)fl、(1.1±0.5)mmol/L、(3.8±0.5)mmol/L、(2.2±0.5)mmol/L]均显著低于对照组[(42.5±9.7)%、(105.2±30.1)ng/L、(53.3±6.9)fl、(2.0±0.6)mmol/L、(5.4±0.6)mmol/L、(5.4±0.6)mmol/L],差异有统计学意义(均P<0.05),高密度酯蛋白(HDL-C)升高的幅度[(1.9±0.5)mmol/L]大于对照组[(1.1±0.4)mmol/L],差异有统计学意义(P<0.05);实验组患者治疗总有效率85%明显高于对照组68%,差异有统计学意义(P<0.05);实验组和对照组患者治疗不良反应分别为6.0%,14.0%,差异有统计学意义(P<0.05)。结论复方丹参滴丸治疗急性缺血性脑卒中,较纯西医用药更有效,可改善血小板参数及血脂水平并降低不良反应,且安全性较高。 Objective To observe the clinical effect of Compound Danshen dripping pills and Western medicine in the treatment of acute ischemic stroke patients.Methods A total of 200 patients with acute ischemic stroke from January 2014 to January 2017 were selected as subjects. Subjects were randomly divided into experimental group（100 cases） and control group（100 cases）. The patients in the control group were treated with conventional symptomatic treatment. The experimental group was treated with compound Danshen Dropping Pill on the basis of routine symptomatic treatment. The platelet parameters, changes in lipid parameters, clinical efficacy and occurrence of adverse reactions were observed in the two groups. Results The levels of platelet aggregation, plasma thromboxane B2, mean platelet volume, triglyceride（TG）, total cholesterol（TC） and low density ester protein（LDL-C） were significantly lower in the experimental group than in the control group（all P〈0.05）. The increase of HDL-C in the experimental group was significantly higher than that in the control group（P〈0.05）. The total effective rate was 85%（85/100） in the experimental group and 68%（68/100） in the control group. The total effective rate was significantly higher in the experimental group than in the control group（P〈0.05）. The occurrence of adverse reactions in the experimental group and the control group were 6.0%（6/100） and 14.0%（14/100）, respectively. The difference was statistically significant（P〈0.05）. Conclusion Compound Danshen dripping pills combined with western medicine is more effective than pure western medicine in the treatment of acute ischemic stroke and can improve the platelet parameters and lipid levels compared with pure Western medicine. Besides, combination therapy can reduce adverse reactions and with high safety and good tolerance.

关 键 词： 急性脑卒中 复方丹参滴丸 血小板 血脂