作　　者： (陈正君）; (卢年华）; (赵慧巧）; (芦彦兆）; (陈晖）; (景明）;

机构地区： 甘肃中医药大学期刊编辑部,甘肃兰州730000

出　　处： 《甘肃中医药大学学报》 2017年第4期19-23,共5页

摘　　要： 目的对制取的具pH依赖型和酶触依赖型的微丸进行模拟体内环境试验,以判断制备复方湿生扁蕾结肠靶向微丸的可行性。方法结合反相高效液相色谱(RP-HPLC)法,以湿生扁蕾中所含木犀草素为评价指标,结合2015版《中华人民共和国药典》中释放度测定法,评价微丸在模拟胃液、小肠液、结肠液中的释药行为。结果复方湿生扁蕾微丸中木犀草素在模拟胃液和小肠液中2 h后均未见释放;在模拟结肠液中1 h后释放度为85.3%,2 h后达95.3%。结论制备的复方湿生扁蕾结肠靶向微丸释放度满足《中华人民共和国药典》要求,工艺可靠,重现好,能达到预期释药效果。 Objective To determine the preparation feasibility of Gentianopsis paludosa colon-targeting pellets by simulating environment in vivo for the pH-dependent and enzyme-dependent pellets which are prepared. Me- thods According to the release measurement recorded in Chinese pharmacopoeia （2015） , the content of luteolin was taken as the evaluation index to determine the release degree of the pellets in simulated conditions of gastric, in- testinal and colonic juice with the help of RP-HPLC. Results Luteolin was neither released in simulated gastric juice,nor in intestinal juice in 2 hours. But its release rate was 85.3% in colonic juice in 1 hour and even reached 95.3% in 2 hours. surement in Chinese release effect. Conclusion The dissolution rate of prepared colon-targeting pellets is in line with the mea- pharmacopoeia. The preparation technology is reliable and reproducible which gets the desired

关 键 词： 复方湿生扁蕾 结肠靶向微丸 释放度 反相高效液相色谱