作　　者： (高汉媛）; (王维红）; (颜春鲁）;

机构地区： 甘肃中医药大学中医临床学院,甘肃兰州730000

出　　处： 《甘肃中医药大学学报》 2017年第4期1-4,共4页

摘　　要： 目的观察铺灸对佐剂型关节炎(AA)大鼠血清白细胞介素-2(IL-2)、免疫球蛋白G(IgG)、一氧化氮(NO)的影响。方法将48只Wistar大鼠随机分为4组,即空白组、模型组、药物组、铺灸组。用弗氏完全佐剂复制AA大鼠模型。造模3 d后,药物组给予尪痹颗粒治疗,铺灸组给予铺灸治疗。观察大鼠造模前后及治疗后一般情况的变化;治疗结束后股静脉采血,采用放免法检测血清IL-2,IgG水平,采用化学法检测血清NO水平。结果与空白组比较,模型组大鼠血清IL-2水平显著降低,IgG,NO水平显著升高,2组比较差异均有统计学意义(P<0.01);与模型组比较,药物组和铺灸组大鼠血清IL-2水平显著升高,IgG,NO水平显著降低,差异均有统计学意义(P<0.05或P<0.01),且铺灸组改善作用较药物组更为显著(P<0.05)。结论铺灸能明显改善AA大鼠的一般状况及免疫功能,作用优于尪痹颗粒。 Objective To observe the effects of long snake moxibustion （pujiu） on IL-2, IgG and NO in se- rum of rats with adjuvant arthritis （AA）. Methods 48 Wistar rats were randomized into blank group, model group, medicinal group and pujiu （long snake moxibustion） group. AA rat models were made by Freund＇ s com- plete adjuvant （FCA）. On 3rd day after modeling, medicinal group was given Wangbi Keli, pujiu group was treated with long snake moxibustion. The general condition of rat was observed before and after modeling as well as after treatment. The level of IL-2 and IgG were tested by radioimmunoassay and that of NO by chemical method in blood sampling of femoral vein. Results Compared with blank group, IL-2 in model group decreased while IgG and NO increased ,the difference was statistically significant （P〈0.01）. Compared with model group ,IL-2 in medicinal and pujiu group increased while IgG and NO decreased, the difference was also significant （P〈0.05 or P〈0.01 ）. The improving effect in pujiu group was more remarkable （P〈0.05）. Conclusion Long snake moxibustion can im- prove general condition and immune function of AA rats. It is more effective than bv usinz Wangbi Keli alone.

关 键 词： 佐剂型关节炎 铺灸 白细胞介素 免疫球蛋白 一氧化氮 大鼠 实验研究