作　　者： (陈逸玚）; (李清清）; (安琼）; (刘家言）;

机构地区： 南京医科大学康达学院,江苏连云港222000

出　　处： 《常州工学院学报》 2017年第3期44-47,共4页

摘　　要： 含氧硫杂环骨架化合物具有重要的药物和生物活性。以苯甲酰甲醛和α-硫氰基苯乙酮为原料,乙醇为溶剂,三乙胺为催化剂,在室温下合成了新的1,3-氧硫杂环衍生物。该方法具有起始原料简单易得、环境友好、后处理方便等优点。产物结构经核磁共振氢谱和高分辨质谱进行了测定。 Heterocyclic compounds containing oxygen and sulfur have important pharmacological and biological activities. A kind ofnew 1,3-oxathiole derivative has been synthesized through the reaction of 2- oxo-2-phenylacetaldehyde and 1-phenyl-2-thiocyanatoethanone in ethyl alcohol at room temperature with the catalyst of triethylamine. This method has the advantages of easy availability of reactants,environmental friendliness and convenient aftertreatment. The structure of the product has been characterized by hydrogen nuclear magnetic resonance and high-resolution mass spectrometer.

关 键 词： 苯甲酰甲醛 硫氰基苯乙酮 氧硫杂环衍生物 串联合成