作　　者： (李佩）; (刘鹏）; (张鹏）; (钟诚）; (贾伟）; (尤建鹏）;

机构地区： 榆林市第二医院心血管内二科,榆林719000

出　　处： 《世界中医药》 2017年第8期1812-1815,共4页

摘　　要： 目的:探讨芪参益气滴丸联合曲美他嗪治疗慢性心力衰竭患者疗效观察及对患者心肌和血脂的影响研究。方法:选取2014年6月至2016年6月期间榆林市第二医院收治的冠心病慢性心力衰竭患者94例,依据随机数字表法将94例冠心病慢性心力衰竭患者随机分为观察组与对照组,每组47例。对照组给予曲美他嗪治疗,观察组在对照组基础上结合芪参益气滴丸治疗。2组患者疗程均为8周。比较2组治疗疗效,治疗前后心功能、BNP、心肌酶和血脂指标变化,及不良反应情况。结果:观察组总有效率(93.62%)高于对照组(74.47%),差异有统计学意义(P<0.05);2组LVEF治疗后增加,而LVEDD、LVESD、BNP、CK、CK-MB、TG、LDL-C及TC治疗后下降,差异有统计学意义(P<0.05);观察组LVEF治疗后增加,而LVEDD、LVESD、BNP、CK、CK-MB、TG、LDL-C及TC治疗后低于对照组,差异有统计学意义(P<0.05);2组均未出现严重不良反应。结论:芪参益气滴丸联合曲美他嗪治疗冠心病慢性心力衰竭患者疗效显著,且可改善患者心肌酶和血脂,无严重不良反应,安全可靠。 Objective： To study the efficacy of Qishen Yiqi Dripping Pill combined with trimetazidine on the treatment of chronic heart failure of coronary heart disease and its effect on myocardium and blood lipid. Methods： A total of 94 patients with chronic heart failure due to coronary heart disease were randomly divided into observation group and control group with 47 cases in each group. The control group was given trimetazidine,while the observation group was additionally given Qishen Yiqi Dripping Pills,lasting for 8 weeks as the treatment of course. the therapeutic effect and changes in cardiac function,BNP,myocardial enzyme index,blood lipid index and adverse reaction of the two groups before and after the treatment were compared. Results： The total efficiency of the observation group（ 93. 62%） was higher than that of the control group（ 74. 47%）（ P 0. 05）. LVEF of both the two group increased after the treatment,while LVEDD,LVESD,BNP,CK,CK-MB,TG,LDL-C and TC decreased after the treatment（ P 0. 05）; LVEF of the observation group increased after the treatment,while LVEDD,LVESD,BNP,CK,CK-MB,TG,LDL-C and TC lower than those of the control group after the treatment（ P 0. 05）. There was no severe adverse reaction in the two groups. Conclusion： Qishen Yiqi pill combined with trimetazidine Sibutramine in treating chronic heart failure due to coronary heart disease,safe and reliable,has obvious curative effect and can improve the myocardial enzymes and blood lipid in patients with no serious adverse reaction.

关 键 词： 芪参益气滴丸 曲美他嗪 冠心病慢性心力衰竭 疗效 心肌 血脂