作　　者： (周莉莉）; (张凤鸣）; (王红）;

机构地区： 北京丰台医院肿瘤科,北京100070

出　　处： 《世界中医药》 2017年第8期1796-1799,共4页

摘　　要： 目的:研究分析中药联合化疗治疗中晚期非小细胞肺癌(Non-Small Lung Cancer,NSCLC)的近期临床疗效,以为临床应用提供依据。方法:随机选取2012年2月至2016年12月期间于我院进行治疗的中晚期NSCLC患者148例,并分为2组,联合组使用中药榄香烯治疗联合化疗,化疗组使用单纯化疗,经过3个周期的治疗后,观察比较2组患者的近期疗效,癌胚抗原(CEA)水平变化、生命质量及体力改善情况。结果:联合组治疗后,总有效50.0%,化疗组为28.38%(χ~2=7.258,P<0.05)。联合组KPS评分治疗后由(67.05±6.80)分提高到(73.45±5.47)分,CEA水平由(21.37±4.33)μg/L,降低至(13.01±2.64)μg/L;化疗组KPS评分由(67.01±7.04)分提高到(78.58±4.89)分,CEA水平由(22.18±4.50)μg/L降低至(8.99±1.89)μg/L;联合组的生理情况、社会家庭情况、情感、功能和肺癌症状评分分别为(19.25±3.45)分、(18.76±2.91)分、(18.42±2.31)分、(19.33±2.34)分和(24.06±3.57)分;对照组分别为(13.93±2.12)分、(14.63±3.42)分、(13.37±2.68)分、(16.27±2.85)分和(19.58±3.43)分;组间比较P<0.05。结论:中药榄香烯联合化疗治疗中晚期非小细胞肺癌的近期临床疗效较好,可显著降低CEA水平,治疗总有效率高,体力改善程度大,并能提高患者生命质量。 Objective： To study the clinical efficacy of traditional Chinese medicine with chemotherapy in the treatment of nonsmall-cell lung cancer（ NSCLC） at advanced stage in the treatment of non-small lung cancer（ NSCLC） in Chinese traditional Chinese medicine,to provide references for clinical application. Methods： A total of 148 cases with advanced NSCLC treated in the hospital from February 2012 to December 2016 were selected and randomly divided into two groups. Patients in the treatment group were given elemene combined with chemotherapy,while patients in the chemotherapy group only received chemotherapy. After 3 courses of treatment,the curative effect and changes in carcinoembryonic antigen（ CEA） level,quality of life and physical strength of the two groups were observed and compared. Results： The curative effect rate of the treatment group was 50. 0% and the chemotherapy group was 28. 38%.（ χ~2= 7. 258,P 0. 05）. The KPS score of the treatment group was raised from（ 67. 05 ±6. 80） to（ 73. 45 ± 5. 47）,and the CEA level was reduced to（ 13. 01 ± 2. 64） mu g/L by（ 21. 37 ± 4. 33） mu g/L; the KPS score of the chemotherapy group was raised from（ 67. 01 ± 7. 04） to（ 78. 58 ± 4. 89）,but the CEA level was reduced by（ 22. 18± 4. 50） mu g/L to（ 8. 99 ± 1. 89） mu g/L. The scores of physical condition,social family situation,emotion,function and lung cancer symptom of the treatment group were（ 19. 25 ± 3. 45）,（ 18. 76 ± 2. 91）,（ 18. 42 ± 2. 31）,（ 19. 33 ± 2. 34） and（ 24. 06± 3. 57） respectively; those of the control group was（ 13. 93 ± 2. 12）,（ 14. 63 ± 3. 42）,（ 13. 37 ± 2. 68）,（ 16. 27 ± 2. 85）,and（ 19. 58 ± 3. 43）（ P 0. 05）. Conclusion： The clinical curative effect of traditional Chinese medicine,elemene,combined with chemotherapy for non-small cell lung cancer at advanced stage is good and can significantly reduce the CEA level and improve body strength and quality of life,with great efficiency.

关 键 词： 非小细胞肺癌 中药 化疗 近期疗效