作　　者： (范美君）; (王金龄）; (马锴）;

机构地区： 海南省三亚市人民医院口腔科,三亚572000

出　　处： 《世界中医药》 2017年第8期1793-1795,1799,共4页

摘　　要： 目的:观察大蒜素胶囊联合康复新液治疗复发性口腔溃疡的疗效。方法:选取2016年1月至8月海南省三亚市人民医院口腔科收治的复发性口腔溃疡患者93例,采用随机数表法将患者分为对照组和观察组,分别为46、47例。观察组采用大蒜素胶囊联合康复新液治疗进行治疗,对照组采用康复新液进行治疗。7 d为1个疗程,共治疗2个疗程,观察2组唾液表皮生长因子(EGF)检测水平、T淋巴细胞亚群检测水平、溃疡疼痛持续时间以及溃疡面愈合时间、比较治疗2个疗程后2组患者临床效果。结果:治疗2个疗程后,观察组和对照组唾液表皮生长因子唾液EGF质量浓度(2.86±0.41)ng/m L、(3.85±0.51)ng/m L,血清TNF-α分别为(37.71±5.24)pg/m L、(52.64±11.14)pg/m L,观察组优于对照组,差异有统计学意义(P<0.05);观察组T淋巴细胞亚群检测值D3(82.56±13.47)%、CD4(46.71±5.84)%、CD8(24.41±2.85)%、CD4/CD8(1.83±0.55)%,对照组T淋巴细胞亚群检测值D3(73.75±9.26)%、CD4(32.64±4.14)%、CD8(26.78±2.96)%、CD4/CD8(1.52±0.53)%,观察组优于对照组,差异有统计学意义(P<0.05);观察组溃疡疼痛持续时间和溃疡面愈合时间分别为(3.68±0.95)d、(3.22±0.69)d,观察组疡疼痛持续时间和溃疡面愈合时间分别为(5.78±1.37)d、(5.47±1.61)d,观察组优于对照组,差异有统计学意义(P<0.05)。2组疗效总有效率对照组、观察组分别为为84.7%、97.8%,观察组优于对照组,差异有统计学意义(P<0.05)。结论:大蒜素胶囊联合康复新液治疗复发性口腔溃疡疗效显著,促进溃疡处愈合进程,提升免疫功能,且安全性较好值得临床推广。 Objective： To observe the curative effect of Garlicin capsules combined with Kangfuxin liquid in the treatment of recurrent oral ulcer. Methods： Ninty-three cases of recurrent oral ulcer were randomly selected from January 2016 to August in our hospital,then were divided into treatment group and control group,respectively 46 and 47 cases. The treatment group was given Garlicin capsules combined with Kangfuxin liquid and the control group were treated with Kangfuxin liquid sorely. Treatment course lasts for 7 days,and to perform two courses. Observe salivary epidermal growth factor（ EGF） levels of T lymphocyte subsets level,ulcer pain duration and ulcer healing time of the two groups and compare the clinical effect. Results： After two courses of treatment,salivary epidermal growth factor in saliva EGF concentration in the treatment and control group are（ 2. 86 ± 0. 41） ng/m L,（ 3. 85 ±0. 51） ng/m L,serum alpha TNF-respectively（ 37. 71 ± 5. 24） pg/m L,（ 52. 64 ± 11. 14） pg/m L. The treatment group performs better than the control group,and the difference was statistically significant（ P 0. 05）. In the treatment group,T lymphocyte subsets value are D3（ 82. 56 ± 13. 47） %,CD4（ 46. 71 ± 5. 84） %,CD8（ 24. 41 ± 2. 85） %,CD4/CD8（ 1. 83 ± 0. 55） %,and in the control group,T lymphocyte subsets are D3（ 73. 75 ± 9. 26） %,CD4（ 32. 64 ± 4. 14） %,CD8（ 26. 78 ± 2. 96） %,CD4/CD8（ 1. 52 ± 0. 53） %. The treatment group performs better than the control group,and the difference was statistically significant（ P 0. 05）. The treatment group＇s ulcer pain duration and ulcer healing time was（ 3. 68 ± 0. 95） d,（ 3. 22 ± 0. 69） d,and those are（ 5. 78 ± 1. 37） d,（ 5. 47 ± 1. 61） d in the control group. The treatment group performs better than the control group,and the difference was statistically significant（ P 0. 05）. Effective rate in the control group and treatment group were 84. 7% and 97. 8% respectively,and the treatment group perform

关 键 词： 大蒜素胶囊 康复新液 复发性口腔溃疡 唾液表皮生长因子 淋巴细胞亚群 临床疗效