作　　者： (赵素洁）; (陆怡）; (吴晓琰）;

机构地区： 复旦大学附属华山医院老年病科,上海200040

出　　处： 《中国临床医学》 2017年第3期461-465,共5页

摘　　要： 生长分化因子11(growth differentiation factor 11,GDF11)是转化生长因子β(transforming growth factor-β,TGF-β)家族的一员。GDF11在多种器官和组织中表达。生长发育期间,GDF11通过可逆性地阻滞细胞周期来调节发育进程;在衰老方面,GDF11可延缓心脏、骨骼肌、大脑、骨骼、血管等多个器官和组织的衰老进程。本文就GDF11在生长发育及衰老中的作用及其机制作一综述,以期为GDF11在衰老方面的研究提供指导。 Growth differentiation factor 11（GDF11）, a member of the transforming growth factor β（TGF-β）family, is widely expressed in many tissues.GDF11 regulates multiple developmental processes by reversing cell cycle arrest and reverses the aging process of many tissues including heart, skeletal muscle, brain, bone and blood vessels.In this article, we review the role of GDF11 in aging considering the TGF-β family signaling pathway and the mechanism of GDF11 in growth and development.

关 键 词： 生长分化因子 衰老 转化生长因子