作　　者： (陈晨）;

机构地区： 台州市立医院老年科,浙江省台州318000

出　　处： 《中国基层医药》 2017年第19期2925-2929,共5页

摘　　要： 目的探讨通心络胶囊联合美托洛尔对老年冠心病心绞痛患者的疗效及对血液流变学、炎性因子影响。方法选取老年冠心病心绞痛患者135例，按照随机数字表法分为治疗组68例与对照组67例。治疗组采用通心络胶囊联合美托洛尔治疗，对照组采用美托洛尔治疗。两组疗程均为8周。比较两组疗效，治疗前后心绞痛发作次数和持续时间、血液流变学及炎性因子变化。结果治疗组治疗总有效率（94．12％）高于对照组（76．12％）（P〈0．05）；治疗组治疗后心绞痛发作次数（6．03±1．21）次／周和持续时间（3．02±0．76）min／次，低于对照组的（9．87±1．46）次／周、（4．86±0．98）min／次（t=16．649、12．201，均P〈0．05）；治疗组治疗后全血黏度高切（3．76±0．41）mPa／s、全血黏度低切（8．13±0．76）mPa／s、血浆黏度（1．23±0．08）mPa／s、红细胞聚集指数（2．06±0．27）、纤维蛋白原（2．46±0．41）g/L，低于对照组全血黏度高切（4．53±0．52）mPa／s、全血黏度低切（9．61±0．89）mPa／s、血浆黏度（2．09±0．27）mPa／s、红细胞聚集指数（2．63±0．35）、纤维蛋白原（3．53±0．62）g／L（t=9．562、10．396、25．170、10．604、11．844，均P〈0．05）；治疗组治疗后血清白介素-6（IL-6）（8．49±1．76）pg／mL、细胞间黏附分子-1（ICAM-1）（85．25±8．92）pg／mL、C反应蛋白（CRP）（8．74±1．76）mg／L，低于对照组IL-6（11．32±2．10）pg／mL、ICAM-1（103．42±10．72）pg／mL、CRP（14．98±2．24）mg／L（t=8．491、10．712、18．012，均P〈0．05）。结论通心络胶囊联合美托洛尔对老年冠心病心绞痛患者疗效明显，且可改善患者血液流变学和炎性反应。 Objective To investigate the effect of Tongxinluo capsule combined with metoprolol on elderly patients with coronary heart disease and angina pectoris and its influence on hemorheology and inflammatory factors. Methods 135 elderly patients with angina pectoris of coronary heart disease were selected, and they were randomly divided into treatment group （68 cases） and control group （67 cases）. The treatment group was treated with Tongxinluo capsule combined with metoprolol, while the control group was treated with metoprolol. The two groups were treated for 8 weeks. The curative effect of the two groups was compared, the number and duration of angina pectoris , the changes of hemorheology and inflammatory factors before and after treatment were compared. Results The total effective rate of the treatment group （94.12%） was higher than 76.12% of the control group （ P 〈 0.05 ）. After treatment, the frequency and duration of angina pectoris in the treatment group were （ 6.03 ± 1.21 ） times/week and （ 3.02 ±0.76 ） min/time, respectively, which were significantly lower than those in the control group [ （9.87 ± 1. 46 ） times/ week and （4.86 ± 0.98 ） min/time ] （ t = 16. 649,12. 201, all P 〈 0.05 ）. After treatment, the whole blood viscosity at high shear rate [ （3.76 ± 0.41 ）mPa/s ], whole blood viscosity in low shear[ （8.13 ± 0.76） mPa/s ], plasma viscosity [ （ 1.23 ± 0.08 ） mPa/s ], erythrocyte aggregation index [ （ 2.06 ± 0.27 ） ], fibrinogen [ （ 2.46 ± 0. 41 ） g/L] in the treatment group were lower than those in the control group[ （4.53 ± 0.52 ） mPa/s, （ 9.61 ± 0.89 ） mPa/s, （ 2, 09 ±0.27 ） mPa/s, （2.63 ± 0.35 ）, （ 3.53 ± 0.62 ） g/L ] （ t = 9. 562,10. 396,25. 170,10. 604,11. 844, all P 〈 0.05 ）. After treatment, the interleukin - 6 （ IL - 6） [ （8.49 ± 1.76） pg/mL ], intercellular adhesion molecule - 1 （ ICAM - 1 ）[ （ 85.25± 8.92 ） pg/mL ], C reactive protein （CRP） [ （ 8.74 ± 1.76 ） mg/L ] in t

关 键 词： 通心络胶囊 美托洛尔 冠心病心绞痛 疗效 血液流变学 炎性因子