作　　者： (夏明）; (李慧）; (姬宁宁）; (张发龙）;

机构地区： 徐州医科大学附属医院麻醉科,江苏徐州221002 徐州医科大学江苏省麻醉学重点实验室,江苏徐州221004

出　　处： 《徐州医科大学学报》 2017年第8期513-515,共3页

摘　　要： 目的探讨右美托咪定对乳腺癌根治术患者术后恶心呕吐（PONV）的影响。方法全身麻醉下行乳腺癌根治术患者100例，随机分为右美托咪定处理组（D组）和空白对照组（C组）（n=50），麻醉诱导前分别用微量泵恒速输注右美托咪定0．3wg／kg和生理盐水10ml。所有患者均记录术后1、4、812、24、48h的VAS评分和Ramsay镇静评分并观察术后48h内PONV发生率。结果D组患者术后48h内PONV发生率明显低于c组（P〈0．05）。D组术后1、4、8、12、24、48hVAS评分均显著低于C组（P〈0．05）。2组间各时间点Ramsay评分差异无统计学意义（P〉0．05）。结论0．3μg／kg盐酸右美托咪定能有效预防乳腺癌根治术患者PONV的发生。 Objective To investigate the effects of dexmedetomidine on postoperative nausea and vomiting （PONV） in patients after radical mastectomy. Methods A total of 100 patients undergoing radical mastectomy were randomly di- vided into two groups （ n =50） ： a dexmedetomidine group （ Group D） and a blank control group （ Group C）. Before an- esthesia induction, 0.3μg/kg dexmedetomidine and 10 ml normal saline were separately infused into patients. The VAS and Ramssay scores were recorded 1,4, 8, 12, 24, and 48 h after operation and the incidence of PONV was observed. Results Group D showed a remarkable reduced incidence of PCNV than Group C within 48 h after operation （P 〈 0.05）. The VAS score of Group D was lower than that of Group C 1, 4, 8, 12, 24, and 48 h after operation （ P 〈 0.05）. No statistical difference was found as to Ramsay score between the two groups （P 〉 0.05 ）. Conclusions Dexmedetomidine at 0.3 μg/kg can effectively prevent PONV in patients undergoing radical mastectomy.

关 键 词： 右美托咪定 乳腺癌 恶心 呕吐