作　　者： (柏璐）; (李伟东）; (朱星宇）; (刘玲）; (徐圣秋）;

机构地区： 徐州市第一人民医院药剂科,江苏徐州221002

出　　处： 《徐州医科大学学报》 2017年第8期498-501,共4页

摘　　要： 目的研究苍耳亭对卵清蛋白诱导大鼠过敏性鼻炎的影响。方法采用卵清蛋白诱导大鼠过敏性鼻炎模型，将48只大鼠分成6组：正常组，模型组，苍耳亭高、中、低剂量组，富马酸酮替芬组。给药1周后，记录大鼠打喷嚏和挠鼻数，检测血清中免疫球蛋白E（IgE）和白细胞介素-4（IL-4）的水平，剥取鼻中隔黏膜进行H-E染色及电镜观察。结果苍耳亭可明显减少过敏性鼻炎模型大鼠的打喷嚏和挠鼻数，降低血清中IgE和IL-4的水平，改善鼻黏膜的病理状况。结论苍耳亭对卵清蛋白诱导的过敏性鼻炎模型大鼠有积极的治疗作用。 Objective To investigate the effects of xanthatin on ovalbumin （OVA） induced allergic rhinitis in rats. Methods OVA was selected as antigen to establish a rat model of allergic rhinitis. Forty - eight rats were randomly di- vided into six groups, including a normal group, a model group, a high - , intermediate - and low - dose xanthatin group and a ketotifen fumarate group. After administration for one week, the number of rubbing movement and sneezing of rats was recorded. The levels of serum immunoglobulin E （IgE） and interleukin - 4 （ IL - 4 ） were measured and the changes of rat nasal mucosa were observed by light microscopy after HE staining. Results The number of rubbing movement and sneezing of rats were significantly reduced after treated with xanthatin. Xanthatin could remarkably decrease the levels of serum IgE and IL - 4. In addition, xanthatin markedly alleviated the pathological condition of rat nasal mucosa. Conclu- sions Xanthatin produces significant positive effects against OVA induced allergic rhinitis in rats.

关 键 词： 苍耳亭 卵清蛋白 过敏性鼻炎 大鼠