作　　者： (宁顺宇）; (郜贺）; (杨宇峰）; (石岩）;

机构地区： 辽宁中医药大学,辽宁沈阳110847

出　　处： 《中华中医药学刊》 2017年第9期2421-2426,共6页

摘　　要： 目的:评价川芎嗪(tetramethylpyrazine,TMP)联合用药治疗糖尿病视网膜病变(diabetic retinopathy,DR)的疗效和安全性。方法:通过计算机检索和手工检索收集2000年—2016年16年间以川芎嗪联合用药为干预措施治疗DR的随机对照实验。按Cochrane系统评价方法,由两位研究者独立地对符合纳入标准的试验进行资料提取,并进行研究方法的质量评估和对提取的有效数据进行Meta析。结果:有10个试验,共560例(962眼)DR患者符合纳入标准,Meta分析结果显示,TMP联合用药治疗组与对照组差异显著[OR=3.45,95%CI(2.53,4.72),Z=7.79,(P<0.000 01)],仅有1个试验报道了TMP联合葛根素出现了恶心呕吐、嗜睡、口干等不良反应。结论:川芎嗪联合用药对治疗DR可能有一定疗效,但还需进行更多高质量的RCT才能对其疗效得出肯定性结论。 Objective： To evaluate the safety and efficacy of tetramethylpyrazine（ TMP） combining with other drug in treatment of diabetic retinopathy（ DR）. Method： Randomized trial controlled（ RCT） on TMP combining other drug in treatment of DR was retrieved by computer search and manual collection from 2000 to 2016. There were two researchers independently doing a data extraction according to the inclusion criteria of trials and quality assessment about the method of research and the extraction of valid data was then made based on Meta analysis. Result： Ten RCTs involving 560 patients（ 962 eyes） who met the standards Meta-analysis indicated that compared to control group,TMP treatment group showed significant difference in effective rate [OR = 3. 45,95% CI（ 2. 53,4. 72）,Z = 7. 79,（ P〈0. 000 01） ]. Only one trial reported the adverse reactions occurrence induced by TMP combining with puerarin,such as nausea,vomiting,drowsiness and thirst. Conclusion： Based on the review,TMP combining with other medicine may have positive effect on DR,but more high-quality RCTs are needed in order to draw firm conclusions of large randomized,double blind and placebo-controlled trial.

关 键 词： 糖尿病 糖尿病视网膜病变 川芎嗪 系统评价