导　　师： 叶浩生

学科专业： 040201

授予学位： 博士

作　　者： ;

机构地区： 南京师范大学

摘　　要： 药物依赖的治疗是个世界性难题,其中心理依赖又是关键,相关线索下产生的心理渴求是药物心理依赖的重要原因之一。已有研究从药物线索的条件性作用、联结学习-记忆和奖赏系统的功能等角度阐述相关线索诱发心理渴求对应的脑区。这些研究没能解释相关线索为何能够诱发药物依赖者的心理渴求,而健康人不会对相关线索产生心理渴求。本研究以海洛因戒断者和健康人群为研究对象,采用脑功能影像技术,对相关线索下不同脑区的激活情况进行研究,重点关注探讨镜像神经系统和中脑奖赏环路与药物依赖者心理渴求和复吸行为的可能关系。阐明心理渴求及复吸产生的神经机制,为药物依赖的治疗和预防提供新的线索和方向。 招募13位海洛因成瘾者和12位没有任何物质滥用的健康被试参与实验。实验采用2/(药物戒断和健康对照/)×2/(线索相关性factor1:对照线索和相关线索/)×3/(线索类型factor2:实物线索、工具线索和动作线索/)混合设计。采用西门子磁共振成像系统采集数据。扫描基线与前-后联合连线平行。首先采集被试的解剖定位像,然后采用梯度回波平面成像序列采集功能像。使用SPM8数据处理工具对脑成像数据进行数据预处理和组分析,考察药物相关线索诱发的神经活动及组间、组内差异。 行为数据显示,戒断组和健康对照组被试总体线索反应时无显著差异。两组被试不同类型的线索反应时差异显著,实物线索/(类型一/)反应时显著大于工具线索/(类型二/)的反应时。线索相关性与线索类型两因素的交互作用显著,线索相关性与线索类型的交互作用分析中显示,只有factor2的动作线索反应时在factorl的两个水平上差异显著,即用药动作反应时显著大于对照动作反应时。戒断组在相关线索诱发作用下没有出现明显的心理渴求,他们的心理渴求水平 Finding effective treatments for drug dependency is one of the most challenging issues of modern times and psychological dependence is the key there-into. The cue-induced craving is one of the most main reasons for psychological dependence. The current study targeted the cue-induced craving and use the functional magnetic resonance imaging techniques /(fMRI/) method to study the activation of different areas in the drug dependent individual's brain when they were shown the related cues. The mirror neuron system/(MNS/) will be emphasized in order to illustrate the role and function of MNS during the process of craving elicitation and the possible relationship between the activation of mirror neuron system and craving elecited by drug related cues. Furthermore, we will analysis how the cue elicits the mirror neuron system and reward brain area and how they influence each other. We try to clarify the potential rules of psychological craving after the drug dependence individual has been in withdrawl and hope our research will provide a new thread and direction for the treatment of drug dependence and prevention. 13abstinent heroin dependent individuals /(AHD/) and12no-drug use health participants /(NDP/) involved in the experiment. We conducted2/(groups:abstinent drug dependent group, no-drug use group/)×2/(related condition:related cue, unrelated cue/)×3/(cue types:static object, tool and action/) experiment design. The two within-subject variances constitute six kinds of specific stimulus, including addiction drug and "C-drug"/(drug counterpart cue stimuli/), tool /(paraphernalia/) and "C-tool"/(paraphernalia counterpart cue stimuli/), action /(smoking and injection heroin/) and "C-action"/(action counterpart cue stimuli/).We explored and analysis the neuro activation of cue-induced reactivity and differences between and within groups. All imaging data were acquired on a3.0T MRI scanner /(Siemens Magneto TrioTime syngo/). Anatomical sequence was run first, following the T1scans,36axial slices covering the

关 键 词： 药物依赖 药物相关线索 心理渴求 镜像神经系统 具身认知

领　　域： [哲学宗教]