作　　者： ; ; ; ; (熊晓云）;

机构地区： 中国科学院广州地球化学研究所

出　　处： 《Journal of Chinese Pharmaceutical Sciences》 2004年第1期10-13,共4页

摘　　要： 目的　合成一种前药白藜芦醇烟酸酯。方法　在金属锂片和催化量的萘的存在下 ,3 ,5 二甲氧基苯甲醛与对甲氧基苯甲醇的三甲基硅醚反应经过一系列转变得到白藜芦醇 ,白藜芦醇与烟酰氯反应得到白藜芦醇烟酸酯。结果　设计并合成了白藜芦醇烟酸酯。结论　提供了一种合成白藜芦醇及白藜芦醇烟酸酯的方法 ,采用KHSO4 脱水可选择性的得到反式产物。 Aim To synthesize a new prodrug, resveratrol trinicotinate. Methods Inpresence of lithium and a catalytic amount of naphthalene, the reaction of p-methoxybenzyltrimethylsilyl ether and 3,5-dimethoxylbenzaldehyde gave resveratrol after a series of translation.Resveratrol trinicotinate was obtained by the reaction of resveratrol and nicotinoyl chloridehydrochloride. Results A mutual prodrug resveratrol trinicotinate was designed and synthesized.Conclusion A novel method for synthesis of resveratrol and resveratrol trinicotinate has beenafforded. The E-isomer is selectivily obtained by dehydration of the compound 2 with KHSO_4 .

关 键 词： 白藜芦醇 白藜芦醇烟酸酯 前药 金属锂片 反式产物 合成工艺

领　　域： [化学工程]