机构地区: 西北农林科技大学动物科技学院
出 处: 《动物医学进展》 2004年第2期88-89,共2页
摘 要: 利用体重 19~ 2 2 g的 BAL B/ c-C雌性小鼠 ,通过腹腔注射 ,从急性半数致死量 L D50 和供试鼠的临床表现等方面 ,检查了狗舌草 60 %乙醇提取物冻干粉的急性毒性。结果发现 ,狗舌草 60 %乙醇提取物对雌性 BAL B/ c-C小鼠腹腔注射的 LD50 为 ( 791.2 2± 170 .17) mg/ kg,95 %可信限为 63 9.15~ 979.49m g/ kg。急性死亡小鼠 (剂量达到 3 3 6.11mg/ kg以上 )在死前表现四肢抽搐 ,盲目运动 ,呼吸急促 ,翘尾 ;未死亡的小鼠表现食欲减退 ,反应迟钝 ,在随后的长期饲养中 。 A range of BALB/c-C mice with 19~22g body weight were intraperitoneally administered with anti-lympholeukemic extract from Tephroseris kirilowii Turcz. Holub to measure the LD_(50) and acute toxicity of the extract. The LD_(50) measured in this experiment was 791.22±170.17 mg/kg,with the 95% confidence limit of 639.15~979.49 mg/kg. The acutely dying mice, with dosage 336.11 mg/kg, showed some signs such as twitching limbs, blind movement,puffing and raising tail. And the survivors recovered gradually from anorexia and dullness.